NEURORESTORATIVE ROLE OF HYPERICUM HOOKERIANUM ETHANOLIC EXTRACT ON BRAIN TOTAL ANTIOXIDANT STATUS AND LIPID PEROXIDATION IN HALOPERIDOL INDUCED SCHIZOPHRENIA IN SWISS ALBINO MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 6
Abstract
Schizophrenia is the result of altered cellular homeostasis by oxidative damage in brain which in turn involves in various forms of neurotoxicity including neuronal death. The ethanolic extract of aerial parts Hypericum hookerianum plant has long been used in traditional medicine and in folk treatment for various neurological ailments. The neuroprotective and neurorestorative effect of Hypericum hookerianum was attributed to its antioxidant activity. In the present study the antioxidant potential of Hypericum hookerianum was evaluated in haloperidol induced schizophrenic rat brains. Swiss albino mice of either sex weighing 21-30 g were treated with haloperidol and also treated with Hypericum hookerianum. Oxidative stress was assessed by measuring the extent of lipid peroxidation, total protein content and also totals antioxidant activity in mice brain. Haloperidol stress caused an alteration in oxidative stress markers with a significance increase in brain lipid peroxidation and decrease in total protein content and total antioxidant activities in brain homogenate of treated mice. Hypericum hookerianum has significantly minimized the oxidative stress effects by significant decrease in lipid peroxidation level and also an increase in reduced protein level as well as total antioxidant activities. Results of the present study indicated that Hypericum hookerianum has antioxidant potential against haloperidol -induced oxidative damage in mice brain.
Authors and Affiliations
Uma Pongiya, Badarunnisha , Yalaga Rao
Keywords
Related Articles
- EP ID EP105132
- DOI 10.7897/2230-8407.050697
- Views 79
- Downloads 0
NANOTECHNOLOGY: A PROMISING CARRIER FOR INTRACELLULAR DRUG DELIVERY SYSTEM
Nanotechnology is on its way to make a big impact in Biotech, Pharmaceutical and Medical diagnostics sciences. Nanotechnology holds a tremendous potential when it applied in the fields of drug delivery. In this review it...
ASSESMENT OF PHARMACIST MEDIATED PATIENT COUENSILLING ON HYPERTENSION INCOMPLIANCE WITH QUALITY OF LIFE IN SOUTH INDIAN CITY
To evaluate the effect of counseling in hypertensive patients in terms of their quality of life. A prospective interventional study was conducted in hypertensive patients. Suitably designed and validated Quality of life...
FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLETS OF TRAMADOL HYDROCHLORIDE
The objective of this research work was to develop extended release tablets (Twice in a day) of Tramadol Hydrochloride using different Hydrophilic polymers like HPMC K15M, HPMC K4M, Metalose 60SH50, Carbopol 971P, Sodium...
STUDY ON ENDOCRINOLOGICAL PROFILE OF HIV INFECTED MALE PATIENTS FROM EASTERN INDIA
Human Immunodeficiency virus (HIV) infectionis associated with a variety of endocrine problems. Hypoadrenalism, hypothyroidism and hypogonadism are commonly found singly or in combination. Especially, male hypogonadism i...
PRELIMINARY INVESTIGATION ON THE CHEMOPREVENTIVE PROFILE OF GARCINIA XANTHOCHYMUS
Garcinia species have been reported to possess compounds with antibacterial, antioxidant, apoptotic, hepatoprotective and others biological effects. The Garcinia xanthochymus Hook. f. (Clusiaceae) is a native plant from...