Neutrophil-lymphocyte ratio and creatinine reduction ratio predict good early graft function among adult cadaveric donor renal transplant recipients. Single institution series
Journal Title: Polish Journal of Surgery - Year 2018, Vol 90, Issue 2
Abstract
Background Delayed graft function (DGF) is a common complication following kidney transplantation and is associated with ischemia-reperfusion injury (IRI). Lymphocytes contribute to the pathogenesis of IRI and ischemia-reperfusion related delayed graft function Materials and Methods 135 Caucasian patients received a kidney graft from deceased heart-beating organ donors. We divided patients into 2 groups- patients with the eGFR>=30 on the 21st day post-transplantation (n=36) and patients with the eGFR<30 on the 21st day post-transplantation (n=99) to assess kidney graft function. We measured the serum creatinine levels on 1st and 2nd post-transplant day and preoperative levels of monocytes, lymphocytes, platelets and neutrophils and their ratios. Results We have found statistically significant differences between the eGFR<30 and the eGFR>=30 groups in the average lnLymphocytes (0,36 +/-0,6 vs -0,016 +/-0,74 respectively p=0,004) lnNLR ( 1,27 +/-0,92 vs. 1,73+/-1,08 p=0,016) lnLMR (1,01 +/-0,57 vs. 0,73 +/-0,64 p=0,02), lnPLR (4,97 +/-0,55 vs. 5,26 +/- 0,67 p=0,023) and CCR2% (-20,20 +/- 21,55 vs. -4,29 +/- 29,62 p=0,004 . On univariate analysis, factors of lnLymphocytes >=0,22 (OR=0,331 95%CI 0,151-0,728 p=0,006), lnLMR>=1,4 (OR=0,255 95%CI 0,072-0,903 p=0,034) were associated with worse graft function while lnNLR>=1,05 (OR=2,653 95%CI 1,158-6,078 p=0,021), lnPLR>=5,15 (OR=2,536 95%CI 1,155-5,566 p=0,02) and CRR2 (OR=3,286 95% CI 1,359-7,944 p=0,008) indicated better graft function Conclusion Higher absolute lymphocyte count (lnLymphocytes) and lnLMR as well as lower lnNLR and lnPLR were associated with lower eGFR on the 21st day after kidney transplantation. On multivariate analysis CRR2 in combination with either lnLymphocytes, lnNLR or lnPLR improved the accuracy of detecting patients with poor graft function.<br/><br/>
Authors and Affiliations
Piotr Hogendorf, Anna Suska, Aleksander Skulimowski, Joanna Rut, Monika Grochowska, Aleksandra Wencel, Filip Dziwisz, Michał Nowicki, Dariusz Szymański, Grażyna Poznańska, Adam Durczyński, Janusz Strzelczyk
Keywords
Related Articles
- EP ID EP345562
- DOI 10.5604/01.3001.0011.7499
- Views 107
- Downloads 0
Very High Concentration of D-Dimers in Portal Blood in Patients with Pancreatic Cancer
Gastroenterocolic fistula in the patient after previous gastric resection and hepaticoenterostomy due to complicated ulcer disease – case report
The report presents the case of a patient treated surgically for perforated gastroenterocolic fistula with a concomitant abscess in abdominal integuments and symptoms of the digestive tract blockage. Many months before t...
Gruźlica pęcherzyka żółciowego imitująca nowotwór złośliwy – opis przypadku
Niezwykle rzadko udaje się poprawnie przedoperacyjnie rozpoznać gruźlicę pęcherzyka żółciowego przy braku patognomonicznych cech w obrazie klinicznym i badaniach obrazowych. W niniejszej pracy przedstawiono przypadek 50-...
Risk analysis for the surgical treatment of colorectal cancer in elderly patients undergoing scheduled and urgent interventions
Due to recorded growth both in living standards and latest researches in medicine, proportion of people in old age has significantly improved all over the world. Although old age people are several percent of the entire...
Jatrogenne uszkodzenie dużych naczyń krwionośnych podczas insuflacji jamy otrzewnej w trakcie operacji laparoskopowych
Uszkodzenie dużych naczyń krwionośnych podczas insuflacji jest potencjalnie najgroźniejszym powikłaniem operacji laparoskopowych. Niniejsza praca stanowi analizę przypadków uszkodzenia dużych naczyń krwionośnych, sporząd...