NEW ANALYTICAL METHODS FOR ESTIMATION OF ARTEETHER BY UV AND FLUORESCENCE SPECTROPHOTOMETRY: DEVELOPMENT AND VALIDATION

Journal Title: Journal of Drug Delivery and Therapeutics - Year 2018, Vol 8, Issue 5

Abstract

The present research work discusses the development and validation of two different spectrophotometric methods for estimation of α-β arteether using UV spectrophotometer and spectrofluorimeter for the first time. Two simple, accurate, precise, sensitiveand economical methods has been developed and validated for the estimation of α-β arteether in bulk and pharmaceutical dosage form as per ICH guidelines Q2(R1). The solvent used for UV spectroscopy was methanol and HCl (8:2) and methanol was used for fluorimeter. For qualitative and quantitative analysis, 254 nm was used in UV spectroscopy and excitation and emission wavelengths were set at 354 nm and 697 nm respectively for fluorimetry. Coefficients of correlation were found to be 0.993 and 0.992 for UV spectroscopy and fluorimetry. Both methods show good accuracy and precision and were compared statistically by using two way ANOVA which shows no significant difference between these methods. So the proposed methods were found to have equal applicability for estimation and routine analysis of arteether in pharmaceutical formulations.

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  • EP ID EP494868
  • DOI 10.22270/jddt.v8i5.1797
  • Views 92
  • Downloads 0

How To Cite

(2018). NEW ANALYTICAL METHODS FOR ESTIMATION OF ARTEETHER BY UV AND FLUORESCENCE SPECTROPHOTOMETRY: DEVELOPMENT AND VALIDATION. Journal of Drug Delivery and Therapeutics, 8(5), 151-158. https://europub.co.uk/articles/-A-494868