NEW DELHI METALLO-Β-LACTAMASE 1 (NDM-1) PRODUCING ESCHERICHIA COLI IN BASRAH HOSPITALS. IRAQ
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 2
Abstract
Resistance to carbapenems is developing around the world Escherichia coli(E.coli) resistance to carbapenems is associated with production of carbapenem-hydrolyzing class B metallo-β-lactamases (MBL).New Delhi metallo-β-lactamase 1 (NDM-1) is one of the most recently discovered MBL among E.coli .The present work was aimed to study the prevalence of bla NDM-1 gene among carbapenem-resistant E.coli isolates from six hospitals in Basrah, Iraq Isolates identified and antibiotics susceptibility were assayed by using VITEK2Compact.Phenotypic detection of carbapenemase was performed using combined-disc synergy test (CDST), Chrom ID Carba agar and using RAPIDEC CARBA NP test, isolates were also subjected to the polymerase chain reaction detection of bla NDM-1 gene. Phylogenetic analysis showed very less variation in bla NDM-1 gene with respect to bla NDM-1 possessing by different bacteria Conclusions: Our findings highlight the incidence of bla NDM-1 in E. coli isolates with a reduced susceptibility to Imipenem or meropenem.
Authors and Affiliations
Maytham A. Al-Hamdani
Keywords
Related Articles
- EP ID EP628095
- DOI -
- Views 174
- Downloads 0
SYNTHESIS OF NEW SPIRO[AZETIDINE-2,3ʹ-INDOLINE]-2ʹ,4-DIONES AS POSSIBLE ANTICANCER AGENTS: IN VITRO AND IN SILICO STUDIES
The paper describes the synthesis, and in vitro and in silico biological evaluation of twelve new spiro[azetidine- 2,3ʹ-indoline]-2ʹ,4-diones as possible anti-cancer agents. A series of six compounds have been synthesize...
AN OVERVIEW ON POLYMER GRAFTING
Polymers play a major role in pharmaceutical science as it constitutes an important class of materials by providing suitable substitute for conventional materials. Polymer grafting is a versatile method to modify the pol...
EFFECT OF ETHANOLIC EXTRACT OF GARCINIA KOLA SEEDS ON FOETAL DEVELOPMENT
The incidence of children born with birth defects is 20% higher in Sub Saharan Africa than in developed countries and care must be taken to check the risk factors correlated to birth defects. Garcinia kola is used anecdo...
RED CELL DISTRIBUTION WIDTH: A USEFUL MARKER OF DISEASE ACTIVITY IN INFLAMMATORY BOWEL DISEASE
Background and Objective: Studies concerning red cell distribution width (RDW) for use in the assessment of inflammatory bowel disease (IBD) activity are limited. We investigated whether RDW is a useful clinical marker o...
CEREBRAL VENOUS SINUS THROMBOSIS AMONG SUDANESE PATIENTS IN THE TERM OF CLINICAL PRESENTATION, RISK FACTOR & OUTCOME
Back ground: The cerebral venous sinus thrombosis (CVST) is a rare origin of stroke worldwide. However, the mode of presentation and aetiology are various. The prognosis is better than arterial thrombosis. The age of the...