New Delhi Metallo-β-Lactamases – the dawn of a post-antibiotic era?
Journal Title: Progress in Health Sciences - Year 2012, Vol 2, Issue 2
Abstract
The increasing prevalence of acquired carbapenemases in Gram – negative bacteria is one of the biggest problems in the prevention and therapy of infectious diseases. NDM (New Delhi Metallo--Lactamase) is a recently discovered enzyme which has the ability to hydrolyze all -lactam antibiotics, except aztreonam. Making that scenario more worrisome is the fact that mobile fragments of DNA carrying blaNDM genes, also keeps a number of other genes encoding antibiotic resistance. NDM enzymes are currently present in different species of bacteria all over the world. NDM-producing bacteria are resistant to virtually all available antimicrobial agents except tigecycline, colistine and fosfomycine
Authors and Affiliations
P Majewski, D Ojdana, A Michalska, E Tryniszewska
Keywords
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