New gingerol derivative and other related compounds from Zingiber officinale
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 1
Abstract
In this article we report the isolation, characterization and evaluation of in vitro anti-colon cancer activity of a new gingerol derivative, namely (S,E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradec-8-en-3-one, (N6), and a known sesquiterpene (1,2-Dihydroxybisabola-3,10-diene,N7), isolated from Zingiber officinale rhizomes for the first time, together with other five known compounds; 6-gingerol (N1), 8-gingerol (N2), 10-gingerol (N3), 4-gingerol (N4) and 4`-O-methyl-6-gingerol (N5). The isolated compounds were identified using different spectroscopic techniques (1D and 2D-NMR, MS and IR). A modified chromatographic method was established and optimized to isolate the major gingerols (N1, N2, and N3) in grams.
Authors and Affiliations
Farid A. Badria| Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516 EGYPT, Mai H. El-Naggar| Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516 EGYPT, Fatma M. Abdel Bar| Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516 EGYPT, Mohamed M. Amer| Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516 EGYPT
Keywords
Related Articles
- EP ID EP1467
- DOI -
- Views 411
- Downloads 21
SEROLOGICAL DIAGNOSIS OF HAV AND HEV AND THEIR PREVALENCE IN CLINICALLY SUSPECTED CASES OF ACUTE VIRAL HEPATITIS
NTRODUCTION: ‘Viral Hepatitis’ denotes a primary infection of liver by heterogeneous group of Hepatitis virus. They are clinically indistinguishable, leading to morbidity and mortality. Mainly diagnosed by serological an...
COMPARISON OF MACINTOSH BLADE AND MCCOY BLADE FOR GLOTTIC EXPOSURE AND EASE OF INTUBATION
BACK GROUND: Laryngoscopes forms an important part of general anaesthesia and endotracheal intubation. The aim of laryngoscopy is to obtain good visualization of vocal cords to facilitate smooth...
BILATERAL CONGENITAL GLAUCOMA IN NEUROFIBROMATOSIS TYPE 1 AND MANAGEMENT. (A RARE - CASE REPORT)
Neurofibromatosis 1 is a genetic disorder of neural crest-derived cells. Riccardi classified NF into 8 subtypes NF-I to NF-VIII. NF-V is segmental NF (Prevalence 0.0014 and 0.002%) Caused by a Postzygotic somatic mutatio...
OCCURRENCE OF OVARIAN TUMORS IN KARNATAKA
Ovary is relatively resistant to most diseases except to neoplasms. Ovarian cancer is the fourth leading cause of death in women. The present study included the clinicopathological evaluation of 180 cases of ovarian neop...
Method development and validation using HPLC technique – a review
Analytic method development and validation are key elements of any pharmaceutical development program. HPLC analysis method is developed to identify, quantity or purifying compounds of interest. This article mainly focus...