New Hypoglycaemic Drugs for the Treatment of Diabetes Mellitus and Its Complications: The Future is coming.
Journal Title: Open Access Journal of Urology & Nephrology - Year 2019, Vol 4, Issue 1
Abstract
Diabetes mellitus (DM) has become a growing epidemic over the last few decades. The International Diabetes Federation (IDF) estimates that more than 640 million people will be affected by this condition by 2040. Although the incidence of some of the cardio-vascular complications of DM seems to have shown a decrease over the last years, DM continues to be the main cause of kidney disease, which will require renal replacement therapy (RRT). Many different studies have tried to demonstrate, not always effectively, that the application of clinical practice guidelines and consensus documents may help to stop the onset and progression of the vascular and renal complications of DM. Numerous molecules have also emerged in recent years to improve both the management of DM as well as the onset of micro and macro vascular complications. In this review, we will provide a summary of the metabolic, vascular and renal effects of DPP-4 inhibitors, Glucagon-likePeptide 1 Receptor agonists (GLP-1a) and sodium-glucose co-transporter inhibitors (SGLT2i), especially in patients with diabetic kidney disease with decreased renal function. These new molecules seem to open favorable perspectives in the integrated and multi factorial care of the DM patients.
Authors and Affiliations
Alberto MartÃnez-Castelao
Keywords
Related Articles
- EP ID EP521177
- DOI -
- Views 70
- Downloads 0
Proteinuria as a Marker of Chronic Kidney Disease: A Single Centre Single Day Screening Experience for 9 Years in Varanasi
Introduction: Chronic kidney disease is an asymptomatic devastating medical illness which often results in delayed recognition with direct social and economic consequences for the patients, their families and the country...
Diabetic Kidney Disease: A New Concept for an Old Problem
Diabetes Mellitus (DM) is a growing worldwide epidemic. It was estimated that more than 366 million people would be affected. DM has spread its presence over the world due to lifestyle changes, increasing obesity and eth...
A Case Report of Emphysematous Pyelonephritis in a Diabetic Patient Complicated with Paraspinal Abscess
Emphysematous pyelonephritis is a rare, life threatening condition where there is severe infection of renal parenchyma causing gas accumulation in the tissue. It is commonly in diabetic and needed to be recognised and tr...
Uretero-Arterial Fistula: A Modern Case of an Orphan Disease
Uretero-arterial fistula (UAF) is an uncommon source of hematuria, but as a harbinger of mortality, diagnosis can potentially be lifesaving. While rare, there is a general consensus that the incidence is rising. The cond...
The Importance of Urinary Tract Infections (Utis)
Urinary Tract Infections (UTIs) are significant infectious diseases which may infect different parts of the urinary tract. The UTIs clinical demonstrations involve a variety of signs and symptoms. The level, severity and...