NEW INSIGHTS IN TO SYSTEMIC AMYLOIDOSIS: PRIMARY AMYLOIDOSIS ASSOCIATED WITH TUBERCULAR LYMPHADENITIS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 4
Abstract
Tuberculosis is generally followed by secondary amyloidosis. The association of primary systemic amyloidosis with tuberculosis is very rare. There is only one case thus far reported in literature. We report such a rare case of primary amyloidosis with tuberculous lymphadenopathy. A 45 year old woman presented at the medicine department of all India institute of medical sciences , New Delhi with on & off erythematous rashes over both eyes for 1 year; low grade fever, fatigue and significant weight loss for 4 months, dysphagia for solid food since 1 month. Main finding on examination were pallor, macroglossia, bilateral periorbital erythematous rashes (racoon eyes), hepatomegaly & cardiomegaly. She had raised serum alkaline phosphatase level. Chest x-ray revealed cardiomegaly. USG abdomen revealed multiple retroperitoneal mesenteric lymph nodes and hepatomegaly. USG guided FNAC from mesenteric lymph node showed acid fast bacillus. Histological examination of liver biopsy showed amyloid deposition on congo red stain. Patient was treated with DOTS category I ATT with Bortezomib and Dexamethasone based weekly chemotherapy.
Authors and Affiliations
Shivraj Meena| Senior Resident, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India, Corresponding author email: shivraj.aiims@gmail.com, Nirmal Ghati| Junior Resident, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India, Rita Sood| Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India, Naval Kishore Vikram| Additional Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
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- EP ID EP11289
- DOI 10.5958/2319-5886.2014.00054.x
- Views 244
- Downloads 14
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