New Onset Diabetes after Renal Transplantation (NODAT): Prevalence, Risk Factors and Treatment
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 1
Abstract
Background: This study was conducted to assess the prevalence rate, risk factors and response to treatment of NODAT after renal transplantation. Methods: All consecutive non-diabetic renal transplant recipients (RTR) from 2005 to 2011; done at AIMS, Kochi, were included in the study. ADA criteria (2003) for NODAT was for its diagnosis. Results: The study group included 125 (M:101, F:24) RTRs with a mean age of 31.53 years, with a mean follow-up of 32.01 months after surgery. The prevalence rate of NODAT was 23%. Majority (80 %) of recipients with NODAT, had it within first 6 months after surgery. The prevalence rate of NODAT was higher males and those aged >40 years. The prevalence rate of NODAT was higher in those with family history of diabetes mellitus and pre-transplant impaired glucose levels.The prevalence rate of NODAT was higher with Tacrolimus based regimen and also those receiving methyl prednisolone as part of antirejection therapy. Majority (55 %) of those with NODAT had normal BMI. The prevalence of graft dysfunction was higher in those with NODAT. Conclusions: The prevalence rate of NODAT was 23%, with a peak incidence in initial 6 months after renal transplantation. The non-modifiable risk factors for NODAT were; age > 40 years, male gender, pretransplant impaired glucose levels and family history of diabetes mellitus. The modifiable risk factors for NODAT were; immunosuppressive drugs (Tacrolimus > Cyclosporine A), antirejection therapy with Methyl prednisolone. The prevalence of graft dysfunction was higher in those with NODAT than those without NODAT
Authors and Affiliations
Lakshminarayana GR
Keywords
Related Articles
- EP ID EP213159
- DOI -
- Views 69
- Downloads 0
A Study on Late Complications of Formic Acid Poisoning with Special Reference to Upper Gastrointestinal Tract, Kidney and Eye
Background: Formic Acid is an industrial compound used in the coagulation of rubber latex in Kerala. Easy availability and accessibility of it makes it to be used as an agent of deliberate self harm. However, in literatu...
Tuberculosis of Tongue: A Case Report
Tuberculosis was one of the most prevalent diseases in developing countries more than developed countries. Although incidence of tuberculosis is gradually decreasing due to effective treatment regimen, there are still si...
Evaluation of Awareness of Common Eye Diseases among General Population of Bihar
Objectives: The main objective of this study is to assess the awareness level of common eye related problems in population of Bihar. Material & Methods: a cross-sectional type of study was conducted on 422 general popula...
Comparison of Dexamethasone and Gabapentin alone or in Combination for Controlling Pain in Patients of Adenotonsillectomy
Background: Tonsillectomy is surgical removal of tonsils. It is usually combined with an adenoidectomy, which is the removal of the adenoid. The present study was conducted to assess the role of gabapentin and dexamethas...
Pregnancy after Two Different Modalities of Bariatric Surgery. What to Expect?
Objective: to assess the maternal and neonatal risks of two different bariatric surgical procedures on the following pregnancy regarding obstetric complications and perinatal outcome. Subject and Methods: In this retrosp...