New possibilities of use of oat raw materials for investigation of biologically active components in therapy of experimental diabetes
Journal Title: ScienceRise: Pharmaceutical Science - Year 2017, Vol 0, Issue 5
Abstract
<p>Aim of the work is to suggest the technology of aqua dynamic extraction of bioactive substances from oat straw. The amount of the extract and the concentration of extracted substances depend on the duration of extraction process. The composition of the investigated phytocomplex is established by nuclear magnetic resonance. Fatty acids composition of the phytocomplex of the oat straw extract was studied by gas chromatography. The possibility of using a phytocomplex from an oat straw extract is shown in the study of the metabolism of myocardium lipids in experimental animals with a diabetes model.</p><p><strong>Methods of research:</strong> to optimise the process of aqueous extraction of the oat straw that in prospect, with the help of dynamic character and increased temperatures, can prevail obvious disadvantages of technology offered before; in order to evaluate the differences in the content of the mixtures of the substances, received from the primary extract was noted observation Н1–NMR spectra in D2O; was performed gas chromatographic analysis of the fatty acids spectrum in the studied phytocomplex and in the lipids of the white blood cells of the myocardium; modeling of diabetes was performed by intraperitoneal streptozotocin injection at dose of 55 mg per kilo of body weight of rats during 6 weeks.</p><p><strong>Results:</strong> was developed more economically expedient approach to obtain a phytocomplex by extracting oat straw with full preservation of biologically active substances. Fatty acid composition of the phytocomplex of the oat straw extract was studied by gas chromatography. Composition of the phytocomplex of the oat straw extract was studied by nuclear magnetic resonance</p><strong>Conclusions:</strong> The possibility of using a phytocomplex from an oat straw extract in the study of the metabolism of myocardium lipids in experimental animals with a model of diabetes is shown
Authors and Affiliations
Lyudmila Gayova, Nataliya Yurzhenko, Olga Mysnik
Keywords
Related Articles
- EP ID EP647885
- DOI 10.15587/2519-4852.2017.113503
- Views 107
- Downloads 0
Study of influence of primary packaging on the stability of the original veterinary preparation
<p>A great importance during the design of veterinary drugs is given to the choice of primary package, the material which is directly contact with the dosage form. Stability of samples of veterinary medicines should be i...
Development of method for qualitative analysis of corn silk for implementation in the state pharmacopoeia of Ukraine draft national monograph
According to the concept of development and implementation of monographs on herbal material into the State Pharmacopoeia of Ukraine, Corn silk is included into the list of herbal material, which is described in the State...
Determination of the need for medicinal products of plant origin used for treating cardiovascular diseases
<p><strong>Aim</strong><strong> </strong><strong>of</strong><strong> </strong><strong>the</strong><strong> </strong><strong>study</strong><strong> </strong>is to determine the need for medicinal products of plant origin...
Verification of dissolution test for doxycycline hyclate in capsules to implement into the pharmacopoeial monograph
<p>The study of dissolution profiles is important as a cheap and easy supplement to bioequivalence research, and as a variation to such studies. This method is not outlined in the State Pharmacopoeia of Ukraine for the d...
Розробка методики кількісного визначення фенольних сполук у пижма квітках
<p>Великий асортимент сировини дикорослих лікарських рослин використовують для лікування та виготовлення препаратів на їх основі, однією із таких є пижмо звичайне. Обмежена кількість лікарських препаратів пижма на вітчиз...