NEW SPECTROPHOTOMETRIC DETERMINATION OF PREGABALIN BULK AND PHARMACEUTICAL DOSAGE FORM
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 6
Abstract
A new, selective and sensitive visible spectrophotometric method have been developed for the estimation of Pregabalin in bulk and pharmaceutical preparations. The method is based on the reaction of pregabalin with 2, 3- dichloro-5, 6-dicyano-1, 4-benzquinone (DDQ) to form red colour charge–transfer complex with a λmax. 465nm extracted in methanol. Beer’s law is obeyed in the concentration range of 50 to 250μg/ml for the method. The method is extended to pharmaceutical formulations and there was no interference form any common pharmaceutical excepients and diluents. The result of analysis has been validated statistically and by recovery studies.
Authors and Affiliations
Dr. A. J. Pratapa Reddy| Department of chemistry, K.V.R.P.G College, Nandigama, India.
Keywords
Related Articles
- EP ID EP1406
- DOI -
- Views 437
- Downloads 33
Wound healing activity of the ethanolic extract of Solanum spirale leaves indigenous to north east India
As a part of present work objective are to investigate indigenous plant used in wound healing in northeast India, we hereby reported our findings related to wound healing activities of plant Solanum spirale (Solanaceae)...
Prevalence of anemia among children age 10 to 15 years in urban, Chidambaram
In India, 74% of children and over 50% of adolescent girls and women of reproductive age are anemic.
Controlled release drug delivery system of cardiovascular drug
Conventional medication systems that require multi-dose therapy are with problems. With a view to overcome these problems, the current trend in pharmaceutical research is to design and develop new formulations, thereby e...
Evaluation of Anti diabetic activity of Ethanolic Extract of Beet Root (EEBT- Beta vulgaris) against Streptozocin induced diabetic Rats.
Diabetes mellitus is a heterogeneous group of diseases characterized by chronic elevation of glucose in the blood. It arises because the body is unable to produce enough insulin for its own needs, either because of impai...
BIOCHEMICAL BASIS FOR USE OF CANNABINOIDS IN VARIOUS CLINICAL CONDITIONS
The broad range of potential therapeutic applications of cannabinoids reflects the wide distribution of cannabinoid receptors throughout the body. The possibility of distinct subtypes of cannabinoid receptors and the pr...