NEW SPECTROPHOTOMETRIC DETERMINATION OF PREGABALIN BULK AND PHARMACEUTICAL DOSAGE FORM
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 6
Abstract
A new, selective and sensitive visible spectrophotometric method have been developed for the estimation of Pregabalin in bulk and pharmaceutical preparations. The method is based on the reaction of pregabalin with 2, 3- dichloro-5, 6-dicyano-1, 4-benzquinone (DDQ) to form red colour charge–transfer complex with a λmax. 465nm extracted in methanol. Beer’s law is obeyed in the concentration range of 50 to 250μg/ml for the method. The method is extended to pharmaceutical formulations and there was no interference form any common pharmaceutical excepients and diluents. The result of analysis has been validated statistically and by recovery studies.
Authors and Affiliations
Dr. A. J. Pratapa Reddy| Department of chemistry, K.V.R.P.G College, Nandigama, India.
Keywords
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