Abstract

Rheumatoid arthritis is an autoimmune disorder, which leads to progressive articular destruction and disability. There are numerous agents used for treatment of the disease. However, since these agents may not provide remission or lead to serious complications, search for new treatments continues today. Ozone is a complementary therapy applied successfully for long years in treatment of treatment of circulatory disorders, cancer, inflammatory diseases and various metabolic diseases and anti-aging. The effect could be seen in activation of antioxidant defense system, improvement of circulation, oxygen delivery, inhibition of cytokine release in rheumatoid arthritis. But there is need additional studies on the humans of ozone administration.

Authors and Affiliations