NEWER OPHTHALMIC IN SITU GEL OF MOXIFLOXACIN HYDROCHLORIDE: OPTIMIZATION USING BOX BEHNKEN STATISTICAL DESIGN
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 12
Abstract
Objective: The present research work aims at describing the formulation and evaluation of the ocular delivery system of moxifloxacin hydrochloride (MH) based on the concept of ion sensitive in situ gelations. Methods: In situ gel was prepared by a hot method using 0.6% of gelrite, 0.25% hydroxypropylmethylcellulose (HPMC K4M) and 0.023% tamarind gum as bioadhesive polymers for sustained drug release. Optimization was done by Box Behnken Design with different concentration of gelrite (X1), HPMC K4M (X2) and tamarind gum (X3) as independent variables. In situ gel was optimized based on mucoadhesion index (Y1), Gel strength (Y2) and in vitro drug release (Y3). Influence of the quantitative variable on the dependent variable was predicted by a polynomial equation. Results: Infrared spectroscopy excluded any interaction between drug and excipients. The selected independent variables significantly influenced the responses and were able to sustain the drug release. The prepared gel with a pH of 6.8 to 7.4 exhibited non-newtonian flow with no ocular irritation. The formulation remained stable with no change in pH and viscosity after 30 d of stability study. Conclusion: Thus, moxifloxacin hydrochloride (MH) in situ gel is a viable alternative to a conventional delivery system with the properties of sustained drug release, prolonged ocular retention, and improved corneal penetration.
Authors and Affiliations
Mansi Dholakia, Richa Dave, Vaishali Thakkar, Hardik Rana, Mukesh Gohel, Nirav Patel
Keywords
Related Articles
- EP ID EP566089
- DOI 10.22159/ijpps.2018v10i12.26979
- Views 68
- Downloads 0
IN-SILICO DESIGN, SYNTHESIS AND IN VITRO ANTICANCER AND ANTITUBERCULAR ACTIVITY OF NOVEL AZETIDINONE CONTAINING ISATIN DERIVATIVES
Objective: To design, synthesize and in vitro anticancer and antitubercular evaluation of some new isatin derivatives containing azetidinone.Methods: Novel azetidinone containing isatin derivatives were designed by using...
DESIGN AND OPTIMIZATION OF DOXORUBICIN HCL PRONIOSOMES BY-DESIGN OF EXPERIMENT
Objective: The present research work was designed to formulate and optimize doxorubicin HCl proniosomes by design of experiment (DoE). Methods: A 4-factor, 3-level Box-Behnken design was used to explain multiple linear...
SUPPRESSION OF N-NITROSODIETHYLAMINE INDUCED OXIDATIVE RENAL TOXICITY BY SULPHATEDPOLYSACCHARIDE AND AQUEOUS EXTRACT OF ULVA LACTUCA IN RATS
Objective: The ancient tradition habits of consuming seaweeds in Asian and Middle East countries have been made a key part of their diet, and as an antioxidant, sulphated polysaccharides have made a large number of resea...
SILYMARIN ELICITS PARTIAL PROTECTION AGAINST METHOTREXATE-INDUCED HEPATOTOXICITY IN WISTAR RATS
Objective:Â Methotrexate (MTX) is the gold standard in rheumatoid arthritis treatment; however, its continued use is related to hepatotoxicity. Thus, the aim of the present work is to evaluate the protective role of sil...
DESIGN, SYNTHESIS, IN VITRO ANTIOXIDANT AND IN VIVO ANTI-INFLAMMATORY ACTIVITIES OF NOVEL OXADIAZOLE DERIVATIVES
Objective: In the present study, a series of novel 1,3,4-oxadiazole derivatives (3a-3q) were designed, synthesized and evaluated for antioxidant and anti-inflammatory activities.Methods: The title compounds were designed...