Nitroblue Tetrazolium Reduction Test, Malondialdehyde And Ascorbic Acid Levels In Sepsis And Non-Haematological Malignancies
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Malignancies and infections are associated with oxidant – antioxidant imbalance. The plymorphonuclear leukocytes generate huge amount of reactive oxygen species. The end product Malondialdehyde generated is responsible for the damaging effects on DNA and cell membrane. This study was undertaken to assess the oxidative stress using nitroblue tetrazolium scores and malondialdehyde levels, and to assess antioxidation by vitamin C levels in patients with sepsis and non-hematological malignancies. Nitroblue Tetrazoleum(NBT) reduction test, serum Malondialdehyde(MDA) and vitamin C levels were estimated among 30 healthy persons,30 septic cases,30 malignant cases and 30 with both sepsis and malignant cases. All three parameters of all four groups were compared. In our study, NBT & MDA both of which are markers of oxidative stress were increased in patients with sepsis and malignancy when compared with control groups and the p-value< 0.001 was statistically significant. In contrast these groups showed decrease in Vitamin C levels which acts as an antioxidant. Increased NBT and MDA levels serve as diagnostic and prognostic markers for increased oxidative stress in patients with sepsis and malignancy and antioxidant therapy may be initiated for the well being of these patients.
Authors and Affiliations
Dr Swetha M, Dr Padmavathi K, Dr Sudha Parimala
Keywords
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- EP ID EP467682
- DOI 10.9790/0853-1802133337.
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