NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice.
Journal Title: Pharmacological Reports - Year 2008, Vol 60, Issue 5
Abstract
The anxiolytic-like activity of magnesium in mice during the elevated plus maze (EPM) has been demonstrated previously. In the present study, we examined the involvement of NMDA/glutamate receptor ligands on the magnesium effect on the EPM. We demonstrated that low, ineffective doses of NMDA antagonists (the competitive NMDA antagonist CGP 37849, 0.3 mg/kg; an antagonist of the glycineB sites, L-701,324, 1 mg/kg; a partial agonist of the glycine(B) sites, D-cycloserine, 2.5 mg/kg; and the non-competitive NMDA antagonist MK-801, 0.05 mg/kg) administered together with an ineffective dose of magnesium (10 mg/kg) evoked a significant increase in the percentage of time spent in the open arm of the maze (an index of anxiety). Moreover, magnesium-induced anxiolytic-like activity (20 mg/kg) was antagonized by D-serine (100 nmol/mouse), an agonist of glycineB site of the NMDA receptor complex. The present study demonstrates the involvement of the NMDA/glutamate pathway in the magnesium anxiolytic-like activity in the EPM in mice, and that this activity particularly involves the glycine(B) sites.
Authors and Affiliations
Ewa Poleszak, Piotr Wlaź, Andrzej Wróbel, Sylwia Fidecka, Gabriel Nowak
Keywords
Related Articles
- EP ID EP84224
- DOI -
- Views 116
- Downloads 0
Effect of mirtazepine on the CYP2D activity in the primary culture of rat hepatocytes.
Our previous studies carried out on rats showed that mirtazapine given intraperitoneally at a dose of 3 mg/kg, twice a day for two weeks, increased the activity of CYP2D measured as ethylmorphine O-deethylation in liver...
Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population.
The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as a gate-keeper against various kinds of xenobiotics. Several single nucleotide polymorphisms (SNPs) in the MDR1 gene that may influ...
Effects of olanzapine and paroxetine on phospholipase D activity in the rat brain.
Background: Phospholipase D (PLD) plays a key role in a second messenger system producing phosphatidic acid, mediating, among others, serotonin 5-HT2 receptor activity. The aim of the study was to evaluate a possible eff...
Allyl disulfide as donor and cyanide as acceptor of sulfane sulfur in the mouse tissues.
Cytoplasm of mammalian glial cells was reported to contain Gomori-positive cytoplasmic granulation (GPCG), whose biological role is unknown. The present study attempted to discover conditions facilitating GPCG formation...
Ejaculatory dysfunction in streptozotocin-induced diabetic rats: the role of testosterone.
Hyperglycemic and hypoinsulinemic states caused by diabetes mellitus are usually related to some type of sexual dysfunction, resulting in infertility in humans and experimental models, mostly due to their effects on ejac...