No association between the brain-derived neurotrophic factor 196G>A or 270C>T polymorphisms and Alzheimer’s or Parkinson’s disease
Journal Title: Folia Neuropathologica - Year 2006, Vol 44, Issue 1
Abstract
The brain-derived neurotrophic factor (BDNF) promotes survival, differentiation and maintenance of neurons in the central nervous system. BDNF 196G>A and 270C>T polymorphisms have previously been associated with Alzheimer’s disease (AD) and with Parkinson’s disease (PD). To study the role of BDNF 196G>A and 270C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196G>A and 270C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction. No associations were found between the genotypes studied and AD or PD in Finnish patients. Moreover, no interaction between either BDNF polymorphism and the ε4 allele of apolipoprotein E was found. In conclusion, it seems that the BDNF gene does not contribute significantly to the risk of AD or PD in Finnish patients.
Authors and Affiliations
Marika Saarela, Terho Lehtimaki, Juha Rinne, Heini Huhtala, Riikka Rontu, Antti Hervonen, Matias Röyttä, Jukka-Pekka Ahonen, Kari Mattila
Keywords
Related Articles
- EP ID EP128753
- DOI -
- Views 73
- Downloads 0
Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence
Prion diseases or transmissible spongiform encephalopathies (TSEs) are rare neurodegenerative disorders that can be acquired either by direct transmission, inherited through dominant mutations in the prion protein gene o...
Neurodegeneration with brain iron accumulation
Neurodegeneration with brain iron accumulation (NBIA) describes a group of progressive extrapyramidal disorders with radiographic evidence of focal iron accumulation in the brain, usually in the basal ganglia. Patients p...
The role of excitotoxicity in neurodegeneration
A body of evidence suggests that the mechanisms of excitotoxic neuronal damage evoked by excessive or prolonged activation of the excitatory amino acid receptors may be involved in pathogenesis of brain damage in acute i...
Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury
Poly(ADP-ribose) polymerase 1 (PARP-1 EC 2.4.2.30) is a nuclear enzyme that plays an important role in cell survival and death. PARP is involved in DNA repair machinery, however, massive DNA damage leads to overactivatio...
Distribution of metallothioneins in the brain neoplastic cells.
Metallothioneins (MT) are common proteins in animal tissues. These proteinstake part in the homeostasis of the ions of the metals which are necessary for the proper metabolismof the organism (zinc, copper), biosynthesis...