Non-Invasive Vs Invasive Procedures For Detection of H. Pylori Infection in Patients With Gastric Symptoms in Alkharj, Saudi Arabia
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 1
Abstract
Objectives: H. pylori is detectable in nearly 100% of adult patients with duodenal ulcer and about 80% of patients with gastric ulcer. An association between H. pylori and gastric cancer is confirmed. In developing countries, where most children become infected by the age of 10, gastric cancer rates are very high. Diagnosis of Helicobacter pylori is achieved by invasive or non-invasive methods such as upper endoscopy, antral biopsies, H. pylori PCR of antral biopsies, H. pylori ELISA and H. pylori antigen detection in stool through ELISA technique. The aim of the current study is to compare the diagnostic performance of invasive and non- invasive diagnostic methods in the Kingdom of Saudi Arabia. Design & Methods: Patients between with dyspeptic symptoms were enrolled from the Salman Bin Abdel Aziz University Hospital, Al Kharj, Saudi Arabia between O c t / 2 0 13 and S e p t / 2014. Patients responded to a questionnaire to investigate possible dyspeptic symptoms and then underwent. Besides the gastric biopsy, established as the gold standard test, the stool ELISA test and H. pylori ELISA serology were also applied. Results: The diagnostic performance of the HP stool antigen assay was as follows (Table 2): sensitivity of 94.5%, specificity, 96.2%; positive-predictive value, 93%; negative- predictive value, 94%; and concordance of 90.4%. The diagnostic performance of the H. pylori ELISA assay was also high, with a sensitivity of 90.5% and specificity of 92%. Combining the HP stool antigen with the ELISA assay raised the sensitivity to 98%, the specificity to 97%, PPV to 96% and NPV to 95%. Conclusions: The ROC curve showed a good correlation between the compared methods. The standardization of the ELISA test for the detection of H. pylori in stool specimens constitutes a non-invasive diagnostic alternative
Authors and Affiliations
Ibrahim M. Abdel Aziz
Keywords
Related Articles
- EP ID EP210479
- DOI -
- Views 72
- Downloads 0
Skin Manifestations in HIV Positive Children
HIV infection in children is quite common in our country. Skin manifestations constitute one of the most common clinical features in such children and their clinical pattern and severity is more or less in accordance wit...
Clinicopathological Study of Small Bowel and Related Mesenteric Tumour
This is clinicopathological and management study of 25 patients in a tertiary care hospital during period from Nov 2013 to Nov 2015 In the study conducted in our Institute, the incidence is 0.25% of all patients admitted...
Giant Mesenteric Cyst, Presentation as Acute Appendicitis in Adult: A Rare Case Report
Introduction - Mesenteric cysts are uncommon benign abdominal lesions with no classical clinical features. The preoperative diagnosis requires the common imaging modalities but the final diagnosis established only during...
Burden of Anemia and Hemoglobin Response to Iron Therapy in Adolescent Girls of State of Chhattisgarh
Aims and objectives - To define the prevalence of anemia in the adolescent girls of state of Chhattisgarh and to study its epidemiological correlates and response to iron supplementation. Material and methods - Total 490...
Comparative Study of Oxidant Status and Lipid Profile in Vegetarians and Fish Eaters
Atherosclerosis was the leading cause of death and disability in the developed world. Habitual consumption of moderate amount of fish was associated with reduced mortality from coronary heart disease. However the benefic...