Non-neoplastic Kidney Diseases in Adult Tumor Nephrectomy and Nephroureterectomy Specimens in a Southeast Asian Tertiary Medical Center
Journal Title: Vajira Medical Journal: Journal of Urban Medicine - Year 2024, Vol 68, Issue 1
Abstract
OBJECTIVE: Non-neoplastic kidney diseases are concurrently present in up to 15% of patients with renal and ureteral tumors, which have been most studied in the United States. This study was conducted to determine the prevalence and spectrum of renal parenchymal diseases in similar patients from a Southeast Asian academic institution. METHODS: We searched the database of the Department of Anatomical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University (2012–2022) and found 194 adult nephrectomy and nephroureterectomy specimens with renal, renal pelvis, and ureteral tumors. Additional stains included periodic acid-Schiff, methenamine silver, and Masson trichrome. Direct immunofluorescence microscopy was performed on the paraffin tissue sections for immunoglobulin (Ig) G, IgA, IgM, and kappa and lambda light chains. Clinical information, including age, gender, and co-morbidities, was obtained from the electronic medical records. RESULTS: Analysis of the 194 cases demonstrated the average age was 61 years (range: 17-89 years), with 126 males (65%) and 68 females (35%). After re-examination of the non-neoplastic renal parenchyma, 14 cases (7%) had diffused and/or nodular mesangial sclerosis. Diabetic nephropathy (12 cases) and idiopathic nodular glomerulosclerosis (2 cases) were diagnosed and associated with either stage 1 or 2 genitourinary cancers. Another case was diagnosed with atheroembolic renal disease. In all cases, the concurrent renal diseases were not identified during the initial evaluation. CONCLUSION: Examination of the non-neoplastic renal parenchyma is important to identify non-neoplastic kidney diseases, such as diabetic nephropathy, so early treatment may result in improved clinical outcomes for kidney and urothelial cancer patients.
Authors and Affiliations
Nontawat Benjakul, Kammi J Henriksen, Anthony Chang
Keywords
Related Articles
- EP ID EP733094
- DOI http://dx.doi.org/10.62691/vmj.2024.265159
- Views 33
- Downloads 0
Home Blood Pressure Monitoring in Diabetes Patients at Faculty of Medicine Vajira Hospital, Navamindhradhiraj University
Objective: To compare clinical blood pressure with home blood pressure monitoring and prevalence of white coat hypertension in diabetes patients at Faculty of Medicine Vajira Hospital, Navamindhradhiraj University Metho...
Ruptured Pseudoaneurysm of Branch of Profunda Femoral Artery during Revision Total Hip Arthroplasty: a Case Report
A ruptured pseudoaneurysm is a rare but potentially fatal complication during revision total hip arthroplasty. We report a case of a 46-year-old female with a rupture of a pseudoaneurysm at the branch of the left profund...
Hope of Parents in Children with Hearing Impairments: A Qualitative Study
Background: Hope are related to individual perception and ways to reach their goals. Parents who have high level of hopes can cope with their child disability better than parents who are hopeless. Objective: To explore...
Prevalence and Factors Associated with Adverse Outcomes in Discharged Patients with Community-Acquired Pneumonia at the Emergency Department, Vajira Hospital
Objective: This study has objectives to study the prevalence and factors associated with adverse outcomes in discharged patients with community-acquired pneumonia (CAP) at the emergency department, Vajira hospital. Meth...
Acute Cholestatic Hepatitis Induced by Epstein-Barr virus (EBV) Infection in a Child: A Case Report
Primary Epstein-Barr virus (EBV) infection occurs frequently in children and causes various clinical manifestations. The patients may be asymptomatic and spontaneously recover from infection or has severe symptoms with f...