Nonlinear Mixed-Effect Models for Prostate-Specific Antigen Kinetics and Link with Survival in the Context of Metastatic Prostate Cancer: a Comparison by Simulation of Two-Stage and Joint Approaches

Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 3

Abstract

The online version of this article (doi:10.1208/s12248-015-9745-5) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Solène Desmée, France Mentré, Christine Veyrat-Follet, Jérémie Guedj

Keywords

Related Articles

“Fit-for-Purpose” Method Validation and Application of a Biomarker (C-terminal Telopeptides of Type 1 Collagen) in Denosumab Clinical Studies

Biomarkers are used to study drug effects, exposure–response relationships, and facilitate early decision making during development. Denosumab, a fully human monoclonal antibody against receptor activator of nucl...

Use of Quantitative Pharmacology in the Development of HAE1, a High-Affinity Anti-IgE Monoclonal Antibody

HAE1, a high-affinity anti-IgE monoclonal antibody, is discussed here as a case study in the use of quantitative pharmacology in the development of a second-generation molecule. In vitro, preclinical, and clinical data f...

Modelling and PBPK Simulation in Drug Discovery

Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial software packages. These models require species-specific and comp...

Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model

The online version of this article (doi:10.1208/s12248-015-9792-y) contains supplementary material, which is available to authorized users.

Genetic variations in human G protein-coupled receptors: Implications for drug therapy

Numerous genes encode G protein-coupled receptors (GPCRs)-a main molecular target for drug therapy. Estimates indicate that the human genome contains approximately 600 GPCR genes. This article addresses therapeutic impli...

Download PDF file
  • EP ID EP680955
  • DOI  10.1208/s12248-015-9745-5
  • Views 33
  • Downloads 0

How To Cite

Solène Desmée, France Mentré, Christine Veyrat-Follet, Jérémie Guedj (2015). Nonlinear Mixed-Effect Models for Prostate-Specific Antigen Kinetics and Link with Survival in the Context of Metastatic Prostate Cancer: a Comparison by Simulation of Two-Stage and Joint Approaches. The AAPS Journal, 17(3), -. https://europub.co.uk/articles/-A-680955