Nonmosaic Klinefelter Syndrome Successful Conception after TESE/ICSI: A case report
Journal Title: Open Access Journal of Reproductive System and Sexual Disorders - Year 2018, Vol 1, Issue 2
Abstract
Klinefelter syndrome patients are mostly clinically azoospermic, and before the era of TESE, were unable to father genetically their own offspring. Nonmosaic Klinefelter [NMK] patients have chances of fatherhood once sperm is harvested from the epididymal seminiferous tubules and further injected in the ovarian cytoplasm. We report a case of 36y old NMK patient, treated for 3 months with supportive and hormonal medication achieving a pregnancy after TESE/ICSI. This is the first published case of successful conception in a couple with a nonmosaic Klinefelter father in Egypt using TESE/ICSI. Review of the literature for any advantages of mTESE over TESE and conception demonstrated higher pregnancy rates by TESE although the sperm retrieval rate was similar in both techniques. Klinefelter syndrome [KS] was first described in 1942 by Harry Klinefelter [1]. It is the most common chromosomal disorder in men. The estimated prevalence of K Sis 0.2% in the general population, 3% among infertile men, and up to 11% in men with non-obstructive azoospermia [2]. Yet, KS remains frequently under diagnosed, because of the wide phenotypic variation among affected individuals, and the lack of established screening programs. Only 25% of men with KS are diagnosed during their lifetime, with fewer than 10% being diagnosed before puberty [3]. The disorder is categorized by X-chromosome polysomy, with X-disomy [47, XXY] being the most common variant representing about 85%- 95% of the cases. Characteristic features of KS include small testes, hypogonadism, and infertility [4].
Authors and Affiliations
Vasilios Tanos, SayedElAkhras Akhras, Karim Omar ElSaeed, Mohamed Halawa, M Yousef Elsemary, AlyElakhras Elakhras, Gajek Adam
Keywords
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- EP ID EP635587
- DOI 10.32474/OAJRSD.2018.01.000107
- Views 116
- Downloads 0
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