Nonparametric Stepwise Procedure for Identification of Maximum Safe Dose (MSD)
Journal Title: Asian Research Journal of Mathematics - Year 2017, Vol 6, Issue 3
Abstract
In this article we consider identification of maximum safe dose (MSD) in a dose response study for distribution-free endpoints. Where the maximum safe dose is the highest dose level that does not exceed the median toxicity of the zero dose by a predetermined margin. A nonparametric confidence set-based approach was proposed, that is we incorporate Mann-Whitney method with the partitioning principle in a step-down fashion for safety evaluation. A comprehensive study of the familywise error rate for our new procedure was compared with the dose response (DR) procedure via a Monte Carlo simulations. An example from preclinical trial in genetic toxicology was used for illustrative purpose.
Authors and Affiliations
Michael J. Adjabui, Nathaniel K. Howard, Albert Luguterah
Keywords
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- EP ID EP338472
- DOI 10.9734/ARJOM/2017/36377
- Views 60
- Downloads 0
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