Nonspecific resistance in piglets' blood with colienterotoxemia and for specific action of gamma globulin
Journal Title: Біологія тварин - Year 2015, Vol 17, Issue 1
Abstract
The use specific γ-globulin to increase stress resistance and resistance to colienterotoxemia of piglets at weaning is caused by several factors. According to WHO recommendations, one of the most important areas of application of immunoglobulin preparations is the prevention and treatment of bacterial and viral infections. The main immunological properties of antibodies IgG and IgA isotypes are high affinity for pathogens so that they able to neutralize bacterial toxins, reduce the infectivity of viruses, block the attachment of bacteria to cells. Two experiments on pigs of large white breed of 28-day old were conducted. The first experiment was carried out on clinically healthy and pigs with colienterotoxemia. The second experiment was conducted on 2 groups of clinically healthy pigs, with 10 heads in every group. Piglets of experimental group 3 days before weaning were injected intramuscularly specific γ-globulin at a dose of 1 ml/kg of body weight, re-administration of the drug was performed on the 12th day after weaning. Control group of piglets, respectively, in those periods were administered isotonic sodium chloride solution. The clinical manifestation of colienterotoxemia inhibits phagocytosis, as shown by reduced phagocytic activity of blood neutrophils (P<0.01). The content of circulating immune complexes in the serum of ill piglets was significantly higher (P<0.05) than pigs in the control group. The low levels of cellular and humoral (lysozyme activity of blood serum) protective factors, as well as a high content of CIC in piglets from sows after weaning, indicating a negative effect of weaning on immune defenses have been demonstrated. Administration to piglets before weaning specific γ-globulin leads to activation of the immune system in studied animals.
Authors and Affiliations
M. I. Ratsky, O. I. Vishchur, K. B. Smolyaninov, N. A. Broda, N. M. Leshovska, D. I. Mudrak, I. Ye. Solovodzinska
Keywords
Related Articles
- EP ID EP352977
- DOI -
- Views 87
- Downloads 0
Changes in the concentration of follicle stimulating hormone and estradiol in domestic cats during estrus cycle and in applying of synthetic analogue of progesterone
The article presents data on changes in the concentration of follicle-stimulating hormone in the blood of domestic cats during the estrous cycle and the relationship with the concentration of estradiol in serum depending...
Longevity of dairy cows — energy profile
In the study we compared parameters of energy profile in relation to number of lactation of dairy cows. We analysed blod serum to glucose, non-esterified fatty acids, β-hydroxybutyrate, total cholesterol, triacylglycerol...
Peculiarities of non-etherified fatty acids content in carp gills at different concentration of Copper and Zinc in the water
Copper and Zinc are essential for fishes elements with wide spectrum of biological activity; in particular, they are involved in regulation of fatty acids metabolism. Content and ratio of fatty acids in fish meat is dire...
Natural resistance of the Ukrainian grеy cows
The nonspecific resistance analysis of the Ukrainian Grey cows at “Polyvanivka” breeding farm located in Magdalynivka district, Dnipropetrovsk region has been shown. The researches were conducted in winter-stall period o...
Genomic and Blup evaluation of new zeland white breed rabbits by linear accessories
The article shows the results of studies of interline New Zealand White breed rabbits differentiation by C34T myostatin gene and G2464A progesterone receptor gene polymorphism. The highest frequency of C allele by myosta...