Novel Catalyzed Coupling Reaction OfAromatic Heterocyclic Estradiol Derivatives
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 11
Abstract
During the last two decades, there have been considerable interest in the palladium mediated C-C coupling reaction. Last year, the noble Prize in chemistry was awarded to three scientist for their extensive work in palladium chemistry .Palladium catalyzed annulations reaction of alkynes are of eminence for the synthesis of variety of hetero and carbocyclic ring system. Recently palladium alkyne annulations reaction offered useful and convenient route to indoles, benzofuran, benzopyrans, indenones and isocoumarins.Estrogen analogue containing such moieties could be of use as anticancer and antiviral agent . An attempt has been made to synthesize such steroidal molecules .
Authors and Affiliations
Sheeba Shafi
Keywords
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