Novel Cefixime Loaded Citric Acid Dendrimer for Antibacterial Activity against Pseudomonas Aeruginosa and Staphylococcus Aureus
Journal Title: Nanomedicine & Nanotechnology Open Access - Year 2016, Vol 1, Issue 1
Abstract
The principle goal of the study is to blend third era of citrus extract dendrimer and by connecting polyethylene glycol for diminishing systemic poisonous quality which is non-particular and to give delayed release of the drug called Cefixime by expanding the dissemination time of the drug and additionally framework to hinder resistance delivering strains Pseudomonas aeruginosa and Staphylococcus aureus. For safe and specific focusing of drug into the cells without damage of normal blood cells was finished by entrapment of Cefixime drug into the PEGylated dendrimer. The drug loaded formulations was assessed for their in-vitro release studies and physicochemical properties. To ensure efficacy and safety, additionally improved formulations have to be assessed for antibacterial activity and toxicity. This study demonstrated huge delayed release of Cefixime contrasted and non-PEGylated dendrimeric framework.
Authors and Affiliations
Ramadoss k, MadhuSudhan RA, Oruganti SK
Keywords
Related Articles
- EP ID EP282089
- DOI 10.23880/nnoa-16000102
- Views 140
- Downloads 0
Biosynthesis of Silver Nanoparticles by Chlorodesmis Hildebrandtii A. Gepp & E. Gepp Including its Agricultural and Biomedical Implications
The aim of this work was to investigate the biosynthesis of Silver (Ag) Nanoparticles from aqueous extract of green seaweed Chlorodesmis hildebrandtii and its characterization. The synthesized Ag-Nanoparticles were chara...
Inhalable Chitosan Tripolyphosphate Nanoparticles for Extended Release of DTPA into Lung Fluid
Diethylenetriaminepentaacetic acid (DTPA) is a non-toxic chemical agent with strong actinide chelation properties that has been approved for decorporation of internalized radioactive nuclides such as plutonium and americ...
The Surface Property of Graphene
Since its first discovery in 2004 [1], graphene has attracted great interest due to its extraordinary properties [2-4], such as huge surface area, excellent mechanical strength, high flexibility, superb thermal and elect...
Effect of Chemical Treatment on the Degree of Deacetylation of Chitosan
Chitosan wide range of application is highly dependent mainly on the presence of the reactive amino groups and its degree of deacetylation (DDA) is one of the main parameters characterizing chitosan. Chitosan was produce...
Comparison of the Structural Electrical and Optical Properties of CdS Films Deposited by Chemical Bath Deposition and Spray Pyrolysis
Cadmium sulphide (CdS) thin films were obtained by two methods: chemical bath deposition (CBD) and spray pyrolysis (SP). The influence of the preparation technique on the structural, electrical and optical properties of...