Novel Diagnostic and Prognostic Immunological Markers for Chronic Periodontitis in Makkah Community
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 1
Abstract
The Aim: Investigating the role of Pentraxin-3 in comparison to tumor necrosis factor- α as a diagnostic and prognostic marker for chronic periodontitis. Methods: Pentraxin-3 and tumor necrosis factor- α levels were measured by Enzyme-Linked Immunosorbent Assay for Gingival Crevicular Fluid samples of 53 chronic periodontitis patients before and after periodontal treatment as well as from 50periodontally healthy subjects as a control group. Differences between both groups regarding clinical parameters and tested biomarkers were assessed and correlations between them were calculated. Results: The mean values of periodontal parameters were significantly reduced after treatment. Mean Pentraxin-3 and tumor necrosis factor- α levels were higher in chronic periodontitis patients than in the control group with a significant difference between both groups. Furthermore, these levels were reduced after treatment with a highly statistically significant difference. Positive correlations between the mean values of both markers levels, and clinical parameters were found whereas, Pentraxin-3 was more positively correlated. Conclusion: As Pentraxin-3 is more positively correlated with clinical parameters of chronic periodontitis than tumor necrosis factor- α, it could be a better diagnostic and prognostic marker for the disease. However, further large-scale studies on both genders are recommended to confirm their role as prognostic markers.
Authors and Affiliations
Ibtesam K. Afifi
Keywords
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