Novel Pharmaceutical Gels Containing Glyccerihizic Acid Ammonium Salt for Chronic Wounds
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 5
Abstract
Aims: This study aimed at preparing pharmaceutical gels containing Glyccerihizic Acid Ammonium Salt (GAM) for healing of chronic wounds followed by in-vitro and in-vivo characterization of the prepared gels to ensure their suitability, efficacy and safety. Place and Duration of Study: Department of Pharmaceutics, faculty of Pharmacy (El-Minia University) and Department of Histology, Faculty of medicine, El-Minia University, from September 2011 to June 2012. Methodology: Preformulation studies including infra-red and differential scanning calorimetry were performed on the drug and the polymers to confirm their physicochemical compatibility. Pluronic F-127, Carbomer 940, sodium alginate and hydroxypropyl methyl cellulose were used as gelling agents. The gel formulations were evaluated for in-vitro release and characterized for their physicochemical properties. The base that exhibited the highest release rate was subjected to further histological studies in wounded rats to demonstrate the effect of drug concentration on the histopathological changes post applications. Results: Physicochemical compatibility studies demonstrated the absence of interaction between the drug and the polymers. The physical appearance of the prepared gel was accepted. Microscopic examinations confirmed the absence of any particles or grittiness. Sodium alginate-based gels exhibited the highest drug release rate. Statistical analysis showed high significant differences as compared to other formulations (P<0.001). Kinetic studies showed that all formulations exhibited first-order release rate. Histopathological studies demonstrated that wound closure was faster in animals treated with 3% (w/w) drug as compared to those treated with 1% (w/w) drug. No signs of irritation were noticed among all treated animals Conclusion: GAM prepared in sodium alginate base gave the highest in-vitro release pattern, which followed first-order release rate. A concentration of 3% w/w GAM of this base would give better healing effect in a shorter time.
Authors and Affiliations
Usama F. Aly, Heba F. Mansour
Keywords
Related Articles
- EP ID EP344957
- DOI 10.9734/BJPR/2014/7591
- Views 99
- Downloads 0
Effect of Andrographis serpyllifolia Leaves Extract on Experimentally Induced Typhoid Using Salmonella Typhi
Aims: The aim of the study was to evaluate the effect of the standardized ethanolic extract of Andrographis serpyllifolia leaves on experimentally induced typhoid. Study Design: Single dose of 1 ml Salmonella Typhi (106...
Comparative Effect of Antidepressants (Duloxetine) and NSAID (Dexibuprofen) in a New Rat Model of Chronic Pain Induced Depression Associated with Monosodium Iodo Acetate (MIA) Induced Osteoarthritis in Rats
Objective: To evaluate the role of anti-depressants (Duloxetine) and NSAID (Dexibuprofen) in a new rat model of chronic induced depression. Methods: Twenty four male wistar rats were divided into 4 groups of 6 animals e...
A Summary of the Advances in Ophthalmic Drug Delivery via Iontophoresis and Microneedles
Drug delivery to the posterior segment of the eye is a significantly challenging task due to the underlying physiological, anatomical and metabolic constraints. Delivery of drugs through ophthalmic route is significantly...
Ion-pair HPLC Method for the Quantification of Metformin in Human Plasma and Its Application to a Pharmacokinetic Study
Aims: To develop and validate a rapid, selective and sensitive ion-pairing HPLC-UV method for the determination of metformin in human plasma, using a conventional reverse phase column. Study Design: Experimental study. P...
In silico Identification of Novel Potential BACE-1 Inhibitors for Alzheimer’s Disease Treatment: Molecular Docking, Pharmacophore Modeling and Activity and Synthetic Accessibility Predictions
Aims: Alzheimer's Disease (AD) is a progressive neurodegenerative disease accompanied by loss of memory and cognition. With its causes still unknown, one of the main hypotheses related to its pathogenesis is the amyloida...