NOVEL SPECTROPHOTOMETRIC METHODS FOR THE QUANTIFICATION OF DESVENLAFAXINE IN PURE AND PHARMACEUTICAL DOSAGE FORM
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objectives: Two simple, sensitive and economic spectrophotometric methods are developed for the determination of desvenlafaxine in pure and itspharmaceutical formulations.Methods: The developed methods are based upon the reaction of oxidative coupling of desvenlafaxine with 3-methyl-2-benzthiazolinonehydrazone(MBTH) (Method A) and 2, 2’ bipyridyl (Method B) in the presence of ferric chloride. The colored complex produced was measured at 663 nm,522 nm for method A and B respectively against the reagent blank. The optimum experimental parameters for the color productions areselected.Results: Beer’s law is valid within a concentration range of 20-100 μg/ml and 5-25 μg/ml and for method A, B respectively. The percentage recoverieswere found in the range of 99.47±0.1789 for method A and 100.08±0.144 for method B. The limit of detection and limit of quantification were foundto be 0.825 μg/ml and 2.5 μg/ml respectively for method A and 0.1061 μg/ml and 0.321 μg/ml for method B respectively.Conclusion: The developed methods are applied for the determination of desvenlafaxine in bulk and its pharmaceutical formulations without anyinterference from excipients.Keywords: Spectrophotometric, Desvenlafaxine, Oxidative coupling, 3-methyl-2-benzthiazolinone hydrazone, 2, 2- bipyridyl, FeCl3.
Authors and Affiliations
U Sreeja, Bm Gurupadayya, Rs Chandan
Keywords
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