NOVEL SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF SCHIFF BASES OF KETOPROFEN HAVING HETEROCYCLIC MOIETY
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2012, Vol 1, Issue 2
Abstract
A new series of two Schiff bases of ketoprofen having heterocyclic moiety have been synthesized in present investigation. We have tested the anti-inflammatory activities of the synthesized compounds in vivo by using carrageenan induced edema model, using ketoprofen as standard. The safety of these newly synthesized derivatives is reflected by toxicity studies.
Authors and Affiliations
Harendra K. Sharma*| Department of Chemistry, Bethesda Institute of Technology and Sciences, Gwalior (M.P.) India 474006, Manoj Sharma| Department of Pharmacology, Shri RNS College of Pharmacy, Gormi, Bhind, India, Vinay Thakur| Department of Chemistry, Mithibai College, Mumbai (Maharastra) India-400056, Gajanan Pandey| Department of Applied Chemistry, Madhav Institute of Technology and Science, Gwalior-474005 (M.P.) India
Keywords
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