Nuclear morphometric study of Non-Hodgkin's Lymphoma (NHL)
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 5
Abstract
Background: Assessment of nuclear morphology is crucial for the diagnosis of non-Hodgkin's lymphoma. The non-Hodgkin’s lymphomas (NHL) constitute a heterogenous group of lymphoid neoplasms that vary in clinical behavior, histology, immunology and genetic profile. The diversity makes it difficult to diagnose accurately and reproducibly under light microscopy. The nuclear features play a major role in categorizing non-Hodgkin's lymphomas. Materials and methods: The present study was conducted for a period of two years in the Department of Oral Pathology, MNR dental College and Hospital, Sangareddy, Telangana, India. We encountered only three cases of Non-Hodgkin Lymphomas and so we have borrowed the some specimens of NHL from other hospitals in Hyderabad, India. Hematoxylin and Eosin (H and E) stained histological sections were selected and assessed for nuclear area, perimeter and nuclear size of 40 nuclei of tumour cells were measured using the Windows® based image analysis software Results: Total number of cases in our study was 15. The mean nuclear area, perimeter and nuclear size of neoplastic cells were studied. In our study, the mean nuclear area, perimeter and nuclear size of neoplastic cells were significantly high in large cell lymphomas as compared to intermediate cells and small cell lymphoma. P value was significant. Conclusion: Our study supports the assumption that nuclear morphometry offers a more objective and reproducible diagnostic method for subcategorizing lymphoid tumors than is currently possible by conventional histopathological techniques.
Authors and Affiliations
Sridhar Reddy Erugula, P. Sujatha, Ayesha Sameera, B. Suresh Reddy, Jesudass Govada, G. Sudhakar, Kandukuri Mahesh Kumar
Keywords
Related Articles
- EP ID EP426126
- DOI -
- Views 88
- Downloads 0
Effect of Tai-chi on Disequilibrium of Aging (Presbystasis)
Background: Tai Chi Chuan (meaning Supreme Ultimate Force), popularly known as Tai Chi is an internal Chinese martial art practised for both defence and health purposes. Materials and methods: We selected 4 male persons...
Hailey – Hailey Disease: Case Report of a rare disease
Hailey–Hailey disease also known as Familial benign chronic pemphigus is a relatively uncommon disease characterized by painful erosions, vesicles, pustules and scaly erythematous plaques on the neck, axillae, groins and...
Spirometric assessment of pulmonary functions in adult with documented primary hypothyroidism
Introduction: Hypothyroidism is a common endocrine problem, state of deficient thyroid hormones, may be result of many etiologies. Primary hypothyroidism is a subset of Hypothyroidism which accounts for 95% of the cases,...
Role of Ultrasound in Thyroid Pathologies
Disorders of thyroid gland may result from developmental failures, abnormalities of hormone production and structural changes which may or may not be accompanied by changes in function. The normal thyroid gland consists...
Giant peptic ulcer perforation: Omentopexy versus omental plugging - A study
Giant peptic ulcer perforation is a life threatening surgical emergency with high mortality rate. This study compares two different surgical techniques Omentopexy and Omental plugging for the treatment of giant peptic pe...