NUTRIGENOMICS: A NEW PARADIGM FOR REVEALING PERIODONTAL INTERRELATIONSHIPS
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 1
Abstract
Improved understanding of the mechanism behind periodontal tissue devastation, the potential protective role of nutrients and the advent of modern genomic measurement tools have led to an increased interest in the association between nutrition and periodontal disease. Nutrigenomics is an emerging field of science and technology revealing inter-relationships between nutrients and human genome using modern tools such as transcriptomics, metabolomics, epigenomics and proteomics. It implies that nutrition and genetics both play a significant role in the maintenance of human health as well as the development of lethal diseases. Nutrition may be important in redressing the balance between microbial challenge and the host response because it has been implicated in a number of inflammatory diseases and conditions, including type II diabetes mellitus, cardiovascular diseases, rheumatoid arthritis and inflammatory bowel disease, all of which have also been associated with periodontal diseases. Based on the pathology of periodontal disease, the assumption is that specific nutrients which can modulate immune and inflammatory responses could in turn modulate periodontal health. Antioxidant vitamins and trace elements which are known to be depleted during periods of inflammation can counteract reactive oxygen species damage to cellular tissues and modulate immune-cell function through the regulation of redox-regulated transcription factors and ultimately affect the production of cytokines and prostaglandins, thus leading to periodontal changes. Thus we now have the opportunity to study nutrient-gene interactions and how diet affects the inflammatory mechanisms underlying severe periodontitis. Key words: Nutrigenomics, Metabolomics, Proteomics, Transcriptomics, Periodontitis.
Authors and Affiliations
Dr Shilpa Shivanand
Keywords
Related Articles
- EP ID EP417979
- DOI -
- Views 103
- Downloads 0
PREPARATION AND ASSESSMENT OF AMORPHOUS SOLID DISPERSIONS USING VARIOUS METHODOLOGIES
Amorphous products and particularly amorphous solid dispersions are currently one of the most upcoming and widely used areas in the pharmaceutical field. This approach offers huge potential and advantageous features rega...
COLLECTION, PURIFICATION AND PHYTOCHEMICAL SCREENING OF A NATURAL GUM FOR ORAL CONTROLLED DRUG DELIVERY SYSTEM
Present study highlighted that sustained release matrix tablet of Indomethacin using gum karaya (GK) as matrix former. Various concentrations of KG used to ensure the release model. Preformulation study of Indomethacin w...
Insecticidal Activity of Methanolic Extract of Calotropis Procera against Callosobruchus Maculatus using Moong Seeds (Vigna Radiata)
Food quality and safety are directly depending on the worth of raw material used. Screening of plant extracts for deleterious effect on insects is one of the approaches in the search of novel biological insecticides for...
COMPARISION OF LEVELS OF PERIODONTOPATHIC BACTERIA BY POLYMERASE CHAIN REACTION IN CHRONIC AND AGGRESSIVE PERIODONTITIS PATIENTS BEFORE AND AFTER NON-SURGICAL THERAPY WITH SUBGINGIVAL ANTIMICROBIAL (BIOTENE) IRRIGATION.
INTRODUCTION: Periodontitis is an inflammatory disease of the supporting tissues of teeth caused by specific group of microorganisms resulting in destruction of periodontal ligament, alveolar bone with pocket formation...
Interaction of tau proteins and orexin receptors in dementia and allied syndromes
The neuronal and neurobiological basis of cognitive dysfunction accompanying neurodegenerative processes forms an important focal point of research interest in neuroscience. The so-called‚ mild cognitive impairment refer...