Obesity and renal cancer incidence and mortality – a systematic review of prospective cohort studies
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2016, Vol 23, Issue 1
Abstract
[b]Introduction and objective.[/b] There have been many studies published recently on obesity and the risk of renal cancer; however, the epidemiological evidence for such an association has not been consistent. Therefore, a systematic review was conducted of the prospective cohort studies to assess the association between obesity and the risk of renal cancer incidence and death. [b]Materials and methods.[/b] A search was conducted of the PubMed database and references to published studies from inception until May 2013. Guidelines for Assessing Quality in Prognostic Studies on the Basis of Framework for Potential Biases were followed for quality assessment of studies included in the systematic review. [b]Results. [/b]Twenty eligible studies were identified and included in the systematic review. Among the 20 selected studies, overall study quality was high. Although the evidence from the prospective cohort studies, linking obesity with renal cancer incidence, has not been entirely consistent, there is a convincing body of data for a positive relationship. Moreover, cumulative data is compelling for a strong positive association between obesity and fatal renal cancer. [b]Conclusions.[/b] There is a relatively consistent amount of evidence that obesity increases the risk of renal cancer and fatal renal cancer. Further research is needed as better understanding of mechanisms by which obesity may influence renal cancer development and progression will aid the fostering of strategies for prevention and treatment of one of the most lethal human malignancies.
Authors and Affiliations
Tomasz Golabek, Jakub Bukowczan, Piotr Chlosta, Waclaw Lipczynski, Andrzej Borowka
Keywords
Related Articles
- EP ID EP79310
- DOI 10.5604/12321966.1196850
- Views 132
- Downloads 0
Contact eczema of hands caused by contact with potato protein
[b]Introduction. [/b]Protein contact dermatitis (PCD) is an IgE-dependent allergic reaction which, despite enormous progress in knowledge, remains a ‘non-diagnosed’ nosologic unit in contemporary medicine. Skin lesion, w...
Nutrition-related health behaviours and prevalence of overweight and obesity among Polish children and adolescents
Introduction. An adequate mode of nutrition is among the most important environmental factors affecting the development of Man and maintenance of a good health status. An improper selection of nutrients and irregular con...
Evaluation of CD40 and CD80 receptors in the colonic mucosal membrane of children with inflammatory bowel disease
[b][/b][b]Introduction. [/b]The most prevalent inflammatory bowel diseases (IBD) include ulcerative colitis (UC) and Crohn’s disease (CD). Immune processes play a vital role in the etiopathogenesis of these conditions, i...
An assessment of dietary intake and state of nutritional in hypertensive patients from rural and urban areas of Greater Poland
The aim of this study was to determine the nutritional factors connected with the prevalence of hypertension in rural and urban areas of Greater Poland. The study consisted of 308 people aged 35-62, with essential hyper...
Hantavirus RNA not detected in [i]Ixodes ricinus[/i] ticks
A total of 174 unfed[i] Ixodes ricinus[/i] ticks (104 nymphs, 36 males, and 34 females) collected in the Roztocze National Park in eastern Poland were examined by the PCR and nested PCR methods for the presence of hanta...