Obesity, Diabetes and Gastrointestinal Malignancy: The role of Metformin and other Anti-diabetic Therapy
Journal Title: Global Journal of Obesity, Diabetes and Metabolic Syndrome - Year 2018, Vol 5, Issue 2
Abstract
The association between Diabetes and cancer has been known for decades with obesity and insulin resistance being postulated as the main underlying risk factors for both disorders. With rise of the epidemic of obesity in the USA and around the globe, there has been a rise in diabetes that is currently reaching epidemic proportions. Diabetes is known to be associated with increased risk of several types of malignancy including breast, cervical, pancreatic and colon cancer. In this review, we discuss the epidemic of obesity and its consequential epidemic of diabetes highlighting the pathophysiologic mechanisms of increased cancer in the diabetic population. We will then discuss the role of insulin therapy as well as other antidiabetic medications, particularly metformin that has been to be associated with lower risk as well as better survival with GI malignancies based on several studies including a study that was recently published by our group.
Authors and Affiliations
M Ashamalla, I Youssef, A Jayarangaiah, N Gupta, S Iqbal, R Miller, SI McFarlane
Keywords
Related Articles
- EP ID EP533005
- DOI 10.17352/2455-8583.000032
- Views 59
- Downloads 0
Diabetes mellitus and heart diseases
Diabetes mellitus is recognized by World Health Organisation experts as a non-communicable epidemic and represents a serious medical and social problem. In 2012, suffered of diabetes mellitus about 6.4% (285 million) of...
Obesity, Diabetes and Gastrointestinal Malignancy: The role of Metformin and other Anti-diabetic Therapy
The association between Diabetes and cancer has been known for decades with obesity and insulin resistance being postulated as the main underlying risk factors for both disorders. With rise of the epidemic of obesity in...
Complications from Laparoscopic Adjustable Gastric Banding: 364 Cases Experience
Background: Laparoscopic adjustable gastric banding LAGB procedures are part of bariatric surgery, it has been reported with favorable risk-benefit profile like part of the management of obesity. These procedures are eff...
Personalized Indirect Calorimeter for Energy Expenditure (EE) Measurement
Background and aims: A personal indirect calorimeter allows everyone to assess resting and non-resting energy expenditure, thus enabling accurate determination of a person’s total calorie need for weight management and f...
Breath Acetone as Biomarker for Lipid Oxidation and Early Ketone Detection
Former ketone studies, including ketoacidosis (KAD), fasting ketosis (FK), nutritional ketosis (NK), and exercis-eaffected ketosis have brought great advances to the field of ketones. In the present work, blood, urine an...