Observation on Ceruloplasmin Activity in Viral Hepatitis
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 5
Abstract
Objective: The present study was undertaken to the estimation of serum ceruloplasmin in cases of viral hepatitis and its comparative study with other liver function tests (Serum Bilirubin, serum alkaline phosphatase and S.G.P.T). Materials and Methods: A total of 60 patients of viral hepatitis diagnosed clinico-biochemically were included from different units of inpatient medical ward. The estimation of serum ceruloplasmin activity was done by ELISA methods (modified methods of Rabin). Results: Out of 60 patients, 43 (71.66%) were male and 17 (28.33%) were female and male to female ratio was 2.52:1. In control series 19 cases (63.33%) were male and 11 cases (36.67%) were female. Serum ceruloplasmin level in viral hepatitis was ranges from 40.25 to 70 mg% (mean 55.87% + 8.22), serum bilirubin ranges 3 to 15 mg% (mean 7.83% + 2.81), alkaline phosphtase 14 to 36 IU/L units (mean 24.93 + 6.35) and SGPT were ranges 42 to 170 IU/L (mean 98.37 + 35.90). On comparision of ceruloplasmin level with control it was found highly significant. Serum ceruloplasmin in viral hepatitis in relation to serum Bilirubin and SGPT are not highly significant but serum alkaline Phosphatase are highly significant. It is observed that mean serum ceruloplasmin were different in different weeks according to the duration of appearance of clinical Jaundice. It was evident that maximum rise occurred in the first week, and values gradually started falling in subsequent week, and mean values were highly significant statistically. Conclusion: High serum ceruloplasmin value was confirmed in viral hepatitis. The possible cause of rise of serum caruloplasmin in viral hepatitis may be due to its acute phase reactant activity possibly because of biliary obstruction and also assess its significance in diagnosis severity and prognosis of the disease.
Authors and Affiliations
Dr Sanjeev Kamal
Keywords
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