Observational Study of Serum Vitamin D Levels in Children under Five Years Suffering From Pneumonia in A Tertiary Care Hospital – Rims Ranchi
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
OBJECTIVES: Observational study of serum vitamin D levels in children under five years suffering from pneumonia METHOD: A retrospective observational study was carried out in pediatrics OPD and Inpatient department, RIMS ,Ranchi.The study included 95 children with pneumonia and 95 healthy controls who were selected randomly.Serum 25(OH)D levels were detected and estimated by chemiluminescence method. For categorical analysis of the vitamin D status , cut off values of ≥30 ng/mL for sufficiency, 20– 30 ng/mL for insufficiency, 10–20 ng/mL for deficiency, and ≤10 ng/mL for severe deficiency were set .RESULTS: A total of 190 children were enrolled in the study, including 96 girls and 94 boys, ranging in age from 1 month to 5 years.The serum 25(OH)D levels of the 190 children were not normally distributed, with a median of 23.7 ng/mL, typically in the insufficient state. The overall vitamin D status was as follows: 48 cases (26.4%) were in a state of sufficiency, whereas 142 (73.6%) were inadequate. Among the inadequate children, insufficiency was found in 72 cases (53.1%), deficiency in 48 cases (34.6%), and severe deficiency in 22 cases (12.3%). The age and gender between the two groups were matched.CONCLUSION:Vitamin D is involved in regulating innate and adaptive immune functions .Maintenance of adequate vitamin D status may be an effective and inexpensive prophylactic method against pneumonia.
Authors and Affiliations
DrKhushboo Bage, Dr (Prof) M R Akhouri, DrMadivalesh M
Keywords
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- EP ID EP572280
- DOI 10.9790/0853-1804043536.
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