Observational study to see efficacy and Safety profile of Benzoyl peroxide 2.5%, Adapalene 0.1% and its fixed dose combination in mild to moderate grade of Acne Vulgaris
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 9
Abstract
Introduction: Topical therapies are indicated for mild to moderate cases of acne vulgaris. The most commonly used are benzoyl peroxide 2.5% gel and adapalene 0.1% gel. Combination of both BPO-Adaplene in a gel has excellent results with no major side effects and no risk of resistance like antibiotics. Aim: This study was undertaken to find out the efficacy and safety profile of Benzoyl peroxide-adapalene fixed dose topical combination therapy relative to benzoyl peroxide and adaplene monotherapy in patients of acne vulgaris. Material & Method: In this comparative study of 90 patients of either sex, aged 12 years or more, with mild to moderate grade of Acne Vulgaris and with lesions restricted over the face were enrolled and were divided into three different groups of 30 each by sealed envelope method. Group A-patients were treated with BPO 2.5% gel, Group B- with adapalene 0.1% gel and Group-C were treated with BPO-Adapalene combination gel. Single night time application of gel was advised to patient for a period of 12 weeks. The patients were followed up at 0, 2, 4, 8, 12 weeks at each visit. The decrease in the total number of (both inflammatory + non-inflammatory) lesions and side effects were noted. Results: At the end of the 12 weeks treatment, all groups showed significant improvement. The decrease in mean lesion count of group A, group B and group C was 52.6%, 55.2%, and 78.4% respectively at 12th week. Group C had excellent results with better tolerability. Dryness was a common side effect. Conclusion: Fixed dose combination of adapalene-benzoyl peroxide has greater efficacy for treatment of acne vulgaris with comparatively lesser side effects than monotherapies.
Authors and Affiliations
Dr Jaspreet Kaur Saini
Keywords
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