Obstructive Sleep Apnea in Individuals with Down Syndrome: A Meta-Analytic Literature Review
Journal Title: Journal of Sleep and Sleep Disorder Research - Year 2017, Vol 1, Issue 2
Abstract
Objective: Individuals diagnosed with Down syndrome (DS) are predisposed to obstructive sleep apnea (OSA). The aim of this study is to assess the prevalence of OSA and factors associated with OSA in this population. Study Design: Systematic literature review and meta-analysis. Methods: Studies of DS and OSA in the English language through May 2017 were reviewed. Since parental report of symptoms has limited validity related to the diagnosis of OSA, only studies using in laboratory polysomnography to diagnose OSA were included. Results: Twenty three studies examining OSA among 1,469 people with DS were found. Among ten studies using community referred samples, 71.5% of people with DS had OSA, compared to 69.6% in referred community samples suspected of having respiratory events. There was an inverse relationship between apnea hypopnea index (AHI) cutoffs and OSA prevalence as higher cutoffs were associated with somewhat lower prevalence. Examining age groups, adults had a higher prevalence of OSA (90.0%) compared to infants (66.5%) and children between 2-21 years of age (69.9%). Oxygen desaturation and gender did not affect prevalence. Although surgery had less effect on successfully treating OSA among DS individuals compared to those without DS in prior studies, lingual tonsillectomy had the greatest effect (mean AHI decrease of 9.0). Conclusion: OSA appears to occur frequently in children and adults with DS. Untreated, OSA may contribute to health problems and premature death, highlighting the potential importance of identifying OSA among people with DS. Even after traditional surgeries (i.e., adenotonsillectomy, tonsillectomy, adenoidectomy), repeating PSG is highly recommended as residual OSA can persist
Authors and Affiliations
Sharanah Ridore, Swarnalata Debbarma, Racha Nazir, David S. Bennett, Karim Sedky
Keywords
Related Articles
- EP ID EP336007
- DOI 10.14302/issn.2574-4518.jsdr-17-1754
- Views 136
- Downloads 0
Intervention Study to Improve Meal Habit, Sleep Habit, Circadian Typology and School Marks in Japanese Elementary School Students
Purpose: An intervention program was performed to improve meal habit, sleep habit and academic marks at school. This program was called “Super Meal Educational Program” which was supported by Japanese Ministry of Arts,...
Obstructive Sleep Apneas, Cervical Osteophytosis and Sudden Death: A Paradigmatic Case and a Brief Overview of the Literature
Obstructive sleep apnea (OSA) syndrome is a common disease characterized by partial or complete collapse of the upper airway during sleep secondary to functional or anatomical factors. The gold standard method for OSA di...
The Effects of Physical Activity on Sleep among Adolescents and Adults: A Narrative Review
Objective: Examining the correlation between physical activity measures and sleep in normal adolescents and adult population. Methods: A systematic review was conducted on the effects of exercise, its intensity, its f...
Project Sleep: The Role and Effect of a Comprehensive, Multidisciplinary Music Therapy Quality Improvement Program
Sleep is vital for the maintenance of physical health and mental wellbeing. Sleep also plays a cardinal role in the process of healing. It is estimated that 50 to 70 million Americans suffer chronically from sleep distur...
Factors Influencing the Effectiveness of a One-day CBT for Insomnia Workshop
Insomnia is highly prevalent and has severe negative consequences. Cognitive Behavioural Therapy for Insomnia (CBT-I) is an evidence-based treatment that is usually delivered individually. Given the high prevalence, acce...