Occult Hepatitis B in Hemodialysis Patients
Journal Title: Viral Hepatitis Journal - Year 2019, Vol 25, Issue 3
Abstract
Objectives: We aimed to detect occult hepatitis B (OHB) in hemodialysis patients at a higher-risk for OHB. Materials and Methods: The study included 567 patients with chronic renal failure aged 18 years and older who underwent hemodialysis in 10 dialysis centers in İzmir province between May 2013 and July 2013. Hepatitis B surface-antigen (HBsAg), anti-hepatitis B core (HBc) immunoglobulin G (IgG) and anti-HBs were detected by ELISA and HBV-DNA levels with polymerase chain reaction (PCR). Detection of HBsAg negativity with HBV-DNA positivity was considered as OHB. Results: Of 567 patients, 49% were male and the mean age was 62.2 years. All the patients were HBsAg-negative. Isolated anti- HBc IgG positivity was detected in 8 patients while HBV-DNA was negative. Serum HBV-DNA level was 270 IU/mL in only one patient (0.2%) who was anti-HBc IgG-negative. Conclusion: HBsAg alone is not an adequate serological test to detect HBV infection. HBV-DNA should be tested using molecular diagnostic methods in patients with suspected OHB. Further studies investigating cost-effectiveness and the role of PCR in diagnosis are warranted.
Authors and Affiliations
Pelin Adar, Şükran Köse, Bengü Tatar
Keywords
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- EP ID EP676544
- DOI 10.4274/vhd.galenos.2019.2018.0009
- Views 191
- Downloads 0
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