OCCUPATIONAL ASTHMA DUE TO MANGANESE EXPOSURE: A CASE REPORT
Journal Title: International Journal of Occupational Medicine and Environmental Health - Year 2008, Vol 21, Issue 1
Abstract
Manganese belongs to a group of agents called “transitional metals” that are known to induce occupational asthma. How ever, well-documented cases of manganese-induced asthma have been lacking thus far. We have discussed a case of a 42-year-old non-smoking welder with work-related dyspnea. A number of clinical procedures were performed including clinical examination, routine laboratory tests, total serum IgE, skin prick tests to common aeroallergens and manganese nitrate, resting spirometry test, histamine challenge, and a single-blind, placebo-controlled specifi c inhalation challenge with 0.1% manganese chloride solution. Clinical fi ndings and laboratory test results remained normal but a signifi cant bronchial hyperreactivity was found. During the specific inhalation challenge, dyspnea and a signifi cant decrease in forced expiratory volume (FEV1) were observed. An increased proportion of eosinophils and basophils in induced sputum could also be noted at 4 and 24 h after the challenge. The argument for recognizing the condition as occupational asthma was a positive clinical response to the specific challenge test as well as the morphological changes found in induced sputum. To our knowledge, this is the fi rst well-documented case of manganese-induced occupational asthma.
Authors and Affiliations
TOMASZ WITTCZAK, WOJCIECH DUDEK, ANNA KRAKOWIAK, JOLANTA WALUSIAK, CEZARY PAŁCZYŃSKI
Keywords
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