Occupational Exposure of Silica and its Immunological Effects at Tertiary Care Hospital
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 9
Abstract
Silicosis is an age old occupational disease and remains a major global health problem. It is the most prevalent form of pneumoconiosis, is a preventable, but untreatable, environmental pulmonary disease that can be fatal through the impairment of overall health status.The aim was to evaluate the immunological effects of silica by studying prevalence of autoantibodies Antinuclear Antibody (ANA), Anti Ds DNA, Rheumatoid Factor (RF) and Anti Cyclic Citrullinated Peptide Antibody (Anti CCP) in silica-exposed patients without any known autoimmune disease.The study was done amongst 105 persons engaged in the construction and mining industry exposed to silica attending to tertiary care hospital for respiratory diseases in Western India in two year. Prevalence of ANA, ANTI ds DNA, RF & ANTICCP was studied.In the present study about 64.76% patients were smokers and had history of exposure to silica for more than 10 years. Approx. 70% of the patients had tubercular infection. ANA was positive in 19.04%, Anti ds DNA in 13%, RF in 15% and ANTI CCP in 11% of the patients. Stastistically significant correlation was seen between serum ANA and smoking in silica exposed patients.The present study emphasises that there is increased prevalence of humoral immunologic abnormalities in patients with silicosis. Hence the recognition of autoimmune complications is required in persons exposed to silica.
Authors and Affiliations
Dr. Sanidhaya Tak, Dr. Shweta Choudhary, Dr . Mahesh Gupta, Dr . Gopal Purohit, Dr. C. R Choudhary, Dr. Sunil Vyas, Dr. Hemant Borana
Keywords
Related Articles
- EP ID EP479585
- DOI -
- Views 73
- Downloads 0
Anaesthetic Consideration for Caesarean Delivery in a Parturient With Motor Neuron Disease
Abstract: Parturient with pre-existing central nervous system disorder like motor neuron disease poses a unique challenge to the anaesthesiologist. The choice of proper anaesthetic technique is still contentious and depe...
PPIUCD and its Follow up: A Comparative Analysis with Interval IUCD
Abstract: To compare the efficacy and complications of postpartum IUCD with interval IUCD. Method: It was a prospective study conducted in the Department of OBGY, KRH, and Gwalior. A total of 240 females fulfilling the i...
Study of Induction Times of Various Anaesthetic Techniques
The aims and objectives of our study is to analyse the time taken by the anaesthetist for induction during general, spinal, combined spinal epidural and ultrasound guided brachial plexus block ,comparing these with bench...
The Efficacy of Short Wave Diathermy (SWD) in Decreasing the Cost Effect & Time in Treatment of Osteoarthritis (OA) Knee
Osteoarthritis (OA) is by far the most common form of arthritis. It is strongly associated with ageing and is a major cause of pain and disability in older people. Joint pain and stiffness are the most common symptom for...
Study of Trends of Suicidal Deaths in Central Mumbai Region of India
Suicide is one of the largest and most complex social problems that have accompanied man since antiquity. Globally, more than a million deaths accounted, out of which 20% were Indians. Aim of our study is to find out mos...