Occurrence of Mycosis Fungoides in an Iranian Chemical Victim of the Iran–Iraq War with a Long-term Follow-Up: A Case Report and Review of Literature
Journal Title: Iranian Journal of Medical Sciences - Year 2018, Vol 43, Issue 3
Abstract
Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Persistent antigenic stimulation has been claimed to play a role in the development of this malignancy. We aimed to show the role of sulfur mustard in the pathogenesis of MF. A 45-year-old man with MF is introduced herein. He was a victim of chemical exposure in 1987 during the Iran–Iraq war. He developed skin lesions 3 years after exposure to sulfur mustard gas at the age of 21. Seven years after his exposure to sulfur mustard gas, a biopsy from the posterior distal part of his calf, which was injured and had bulla, revealed MF. Later, he developed more lesions on his extremities, trunk, and abdomen. On his previous admission, his left eyebrow was involved. A punch biopsy specimen was obtained from his eyebrow lesion, which rendered diffuse infiltration of atypical lymphocyte cells with some convoluted nuclei and scant cytoplasm admixed with lymphocytes, histiocytes, and mast cells compatible with the nodular stage of MF. At his last admission, a biopsy was obtained from the plaque lesions on his left thigh, and a TCR-γ gene rearrangement of the paraffin block of the plaque lesions revealed positive monoclonality. All the findings supported the MF diagnosis. We concluded that sulfur mustard could be a risk factor for MF development.
Authors and Affiliations
Hossein Mortazavi, Leila Izadi Firouzabadi, Alireza Ghanadan, Hassan Seirafi, Seyed Naser Emadi, Safoura Shakoei
Keywords
Related Articles
- EP ID EP296859
- DOI -
- Views 67
- Downloads 0
Primordial Odontogenic Tumor of Mandible; A Case with Proposed Diagnostic Criteria
Primordial odontogenic tumor (POT) has been included as a new entity in a recent WHO (2017) classification of odontogenic tumors under benign mixed mesenchymal and epithelial tumors.1 Although there is controversy regard...
Multilocus Sequence Typing of the Clinical Isolates of Salmonella Enterica Serovar Typhimurium in Tehran Hospitals
Background: Salmonella enterica serovar Typhimurium is one of the most important serovars of Salmonella enterica and is associated with human salmonellosis worldwide. Many epidemiological studies have focused on the char...
Quality Assessment of Published Articles in Iranian Journals Related to Economic Evaluation in Health Care Programs Based on Drummond’s Checklist: A Narrative Review
Health economic evaluation research plays an important role in selecting cost-effective interventions. The purpose of this study was to assess the quality of published articles in Iranian journals related to economic eva...
Upregulation of Endothelin-1/Endothelin A Receptor Expression Correlates with Heparanase Expression in Ovarian Carcinoma
Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETAR) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival. Limited data are documented regarding...
The Epidemiology of Skeletal Tuberculosis in Northeast of Iran: A Review of 229 Cases
Background: The incidence of tuberculosis (TB) has increased in recent years in both developed and developing countries. Skeletal tuberculosis occurs in approximately 1% of patients with tuberculosis. The present study a...