Ocena ekspresji receptora estrogenowego, progesteronowego i receptora HER2 w wybranych nowotworach złośliwych ślinianek
Journal Title: Otolaryngologia Polska - Year 2013, Vol 67, Issue 5
Abstract
Introduction: The incidence of the malignant tumors of the salivary glands is relatelively low. However, rapid locoregional progression, distant metastases occurrence and high local recurrence rate occurring despite radical surgical treatment, significantly affect the outcome. Malignant tumors of the salivary glands are characterized by low radiosensitivity and poor response to systemic therapy. Therefore there is a need for new targeted therapies which may improve the prognosis. In some aspects, malignant tumors of the salivary glands are similar to breast cancers. Efficacy of hormonal replacement therapy and the treatment with the monoclonal antibody (trastuzumab) in the treatment of breast cancer is well known and confirmed. Criterion determining the qualification for treatment is the presence of hormone receptors and HER2 receptors in the tumor. Aim: The aim of this study was to evaluate the expression of estrogen receptor, progesterone receptor and HER2 in selected salivary gland malignancies. Materials and methods: Study group consisted of 51 patients with the salivary glands cancer. In the study group there were 42 tumors in the parotid gland, 7 tumors of the submandibular gland, 1 in the mucosa of the cheek and 1 tumor in the tongue. Histologically material comprised of muco-epidermoid carcinoma (10), adenoid-cystic carcinoma (8), salivary duct (7), adenocarcinoma (6), squamous cell carcinoma (6), mioepithelial carcinoma (5) and other (9). In all cases immunohistochemical analysis of the estrogen receptor, progesterone receptor and HER2 receptor was performed. Results: The expression of the estrogen receptor was found in 18% of tumors (9 patients). The expression of the progesterone receptor was found in 20% (10 patients). HER2 expression was found in 10% of tumors and was related to only one histological type of tumor – salivary duct carcinoma. Conclusion: HER2 expression in malignant tumors of the salivary glands, especially in salivary duct carcinoma may be of use in future implementation of new targeted therapies based on monoclonal antibodies.
Authors and Affiliations
Wojciech Golusiński, Anna Wegner, Paweł Trzeciak, Marcin Sówka, Andrzej Kopczyński, Małgorzata Bromboszcz
Keywords
Related Articles
- EP ID EP52211
- DOI -
- Views 76
- Downloads 0
Zastosowanie wąskopasmowej endoskopii lupowej (NBI) w śródoperacyjnej ocenie średnio zaawansowanych raków krtani (T2, T3)
Wstęp: Wybór metody leczenia nowotworów krtani w stopniu zaawansowania T2, T3 zależny jest od wyników badania przedmiotowego oraz badań obrazowych. W przypadku endoskopowej mikrochirurgii laserowej (transoral laser micro...
Factors predicting early diagnosis of pediatric laryngotracheobronchial foreign bodies.
Objective: To study the clinical and radiological findings to make early diagnosis of foreign body (FB) aspiration in children Methods: This prospective study was conducted on 45 children below 12 years of age with a c...
Reconstruction after maxillectomy using the temporalis muscle flap – our experience
The aim of study: The study presents a method of a reconstruction of the palatum after maxillectomy.This method is choosen in selected cases of malignant tumors of the maxilla. Material and methods: The method is combine...
Analysis of difficulties occurring during the early auditory screening in children
Introduction: It is assumed that the critical period for diagnosis of hearing disorders is the baby’s first three months of life and that appropriate course and implementation of treatment and/or rehabilitation should be...
36 Międzynarodowe Warsztaty w Grazu – Funkcjonalna Endoskopowa Chirurgia Zatok