Struktura chromosomu bakteryjnego – metody analizy oddziaływań białko-DNA in vivo

Badania prowadzone w ostatnich latach ujawniły, że chromosom bakteryjny wykazuje hierarchiczną organizację. Liczne białka wiążące DNA kondensują chromosom lokalnie oraz zapewniają jego odpowiednie upakowanie w skali glob...

Metabolism of glycosaminoglycans in the course of juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA) is a non-homogeneous autoimmune children’s disease which, despite the applied therapy, has a progressive character with recurrences, leading to damage of joint structures. Progressive...

The classification, structure and functioning of Ago proteins in Eukaryotes

Ago proteins are members of the highly specialized and conserved Argonaute family, primarily responsible for regulation of gene expression. As a part of RNA-induced silencing complexes (RISCs) Ago proteins are responsibl...

Molecular mechanisms associated with recognition of pathogens by receptors of innate immunity

Innate immunity is the first line of the defensive mechanisms protecting the host from invading pathogens. Structures of pathogens called PAMPs (pathogen-associated molecular patterns) are recognized by extra- and intrac...

Ocena szybkości syntezy dopaminy (DA) w wybranych częściach mózgu szczurów z lezją ośrodkowego układu noradrenergicznego po podaniu ligandów receptora 5-HT3