Oddziaływanie elektronów z cząsteczkami o biologicznym znaczeniu
Journal Title: Wiadomości Chemiczne - Year 2015, Vol 69, Issue 9
Abstract
Recent years have witnessed an increase of the interest in the studies of the interaction of electrons with biologically relevant molecules. This has been mainly motivated by the seminal work, where it has been demonstrated that low energy electrons can induce single and double strand breaks in DNA in the energy range below the level of ionization. Since the damage profile as a function of electron energy showed pronounced resonances it was proposed that resonant electron capture could occur at particular molecular components of the DNA as the initial step towards strand breaks. From a series of experiments on electron attachment to DNA building blocks (nucleobases, the sugar moiety and the phosphate unit) became obvious that they effectively capture electrons leading to the formation of low energy resonances associated with the decomposition of the corresponding molecule. Recent dissociative electron attachment experiments on an entire gas phase nucleotide 2’-deoxycytidine-5´-monophosphate give also insight into the molecular mechanism involved, which comprises both direct electron attachment to the backbone and transfer of the excess electron from cytosine to the backbone resulting in single strand breaks. The results further allow an estimate of the relative contribution of these different mechanisms to single strand breaks.
Authors and Affiliations
Janina Kopyra
Keywords
Related Articles
- EP ID EP585177
- DOI -
- Views 112
- Downloads 0
Wpływ montmorylonitu na właściwości reologiczne wodnych dyspersji karboksymetyloskrobi
Water dispersions are usually a colloidal system in which one of the phases is highly dispersed in a second of a continuous nature, called a dispersion medium (in this case it is water). Dispersal is also called the proc...
Farmakologiczna aktywność flawonoidów i aminoflawonów
Aminoflavones belong to a group of flavonoids, compounds commonly found in nature. Their pharmacological and biochemical effects include cytotoxic, antioxidant and antitumor properties. The studies have shown that comple...
Egzopolisacharydy bakteryjne : budowa i funkcje
Exopolysaccharides fulfil protective functions and allow bacteria live in the communities, single or mixed, by facilitating adhesion to surfaces and to each other. Microbes prefer to exist in the form of a biofilm. The t...
Nowiczok(I) i substancje A
When we hear the slogan ‘chemical weapons’, we are usually reminded of a photograph of marching geese, like the blind Ententa soldiers who were darkened after the Ypres chemical attack in Breugel’s painting. After the en...
Modyfikacja chitozanu : krótki przegląd
Chitosan is the most important derivative of chitin, a polysaccharide found in the exoskeleton of shellfish like shrimp and crab. It is a product of deacetylation of chitin under alkaline conditions or enzymatic hydrolys...