Okara Gum: A natural polysaccharide based carrier for preparation of microbially triggered colon targeted drug delivery system
Journal Title: International Journal of Ayurveda and Pharmaceutical Chemistry - Year 2014, Vol 1, Issue 1
Abstract
Colon targeted pulsatile systems are best for drugs which follow chronopharmacological behavior where, night time dosing is required, drugs have high first-pass effect and specific site of absorption in GIT. In this study, colon targeted pulsatile release tablets of atenolol was prepared using press coating technique to treat hypertension in the early hours of the morning. Pulsatile release of atenlol in colon was achieved by press coating of atenolol core tablet using biodegradable polysaccharides. A biodegradable polymer is a polymer in which the degradation results from the action of naturally occurring microorganisms such as bacteria, algae or fungi. The inability of GIT enzymes to digest certain plant polysaccharides (pectin, guar gum, okara gum) is taken as an advantage to develop colon specific drug delivery systems. The aim of this study is to find out the suitability of newer polysaccharide okara gum for colon targeting of atenolol by compression coating atenolol core tablet with okara gum. The minimum coat weight of okara gum require for colon targeting is optimized. OG4 press coated tablet having 250 mg coat weight of okara gum showed 6 hr lag time and near 7 hr T85%, which is applicable pulsatile drug delivery of atenolol for treating early morning hypertension.
Authors and Affiliations
Rajesh A Keraliya, Chirag A Patel, Vipul Keraliya, Madhabhai M Patel
Keywords
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