Oleuropein as a novel anti-diabetic nutraceutical. An overview
Journal Title: Archives of Diabetes & Obesity - Year 2018, Vol 1, Issue 3
Abstract
Among the cardiometabolic diseases, type 2 diabetes mellitus (T2DM) is one of the most diffused worldwide. Pharmacological treatments commonly used present several side effects, and this is driving people to search natural approaches. Olea europaea is currently investigated for its anti-diabetic potential. In particular, oleuropein (OLE), its main bioactive compound, have been demonstrated to exert interesting activities in management of T2DM, including hypoglycemic and antioxidant activities. The purpose of this manuscript is to review the available scientific evidence evaluating the role of OLE in managing T2DM. Among the cardiometabolic disease, type 2 Diabetes Mellitus (T2DM) is greatly diffused in the World, affecting several million people. In last few years, indeed, T2DM was considered as an epidemic [1]. At the base of the T2DM a etiology there is a reduction in β-cells function and/or the presence of insulin-resistance (IR), causing chronically elevated glycemic levels [2,3]. Chronic hyperglycemia, in turn, is one of the main causes of oxidative stress, which is recognized to be the principal responsible for T2DM complications [4-7].
Authors and Affiliations
Giuseppe Annunziata, Maria Maisto, Connie Schisano, Luigi Barrea, Roberto Ciampaglia, Viviana Narciso, Gian Carlo Tenore, Ettore Novellino
Keywords
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- EP ID EP588763
- DOI 10.32474/ADO.2018.01.000113
- Views 78
- Downloads 0
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