Olmesartan in Management of Proteinuria
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 2
Abstract
ABSTRACT Proteinuria is a marker and predictor of cardiovascular morbidity and mortality. Blockade of angiotensin receptor might result in reduction in proteinuria. Olmesartan, an Angiotensin Receptor Blocker (ARB) which is approved for the treatment of hypertension is believed to produce antiproteinuric effects through different mechanisms. The objective of this review is to assess the cause, duration and degree of proteinuria and understand the current place of olmesartan in management of proteinuria associated with Cardiovascular Disease(CVD) and hypertension. We performed a comprehensive search of MEDLINE, PubMed and Google Scholar databases for articles related to Olmesartan and proteinuria (till June 2017). Angiotensin-II induces transforming growth factor-β upregulation and increase transcapillary pressure. AT-I receptor blocked by olmesartan result in reduction in proteinuria. Olmesartan significantly reduces Blood Pressure (BP) and delays the onset of Chronic Kidney Disease (CKD), it also delayed the risk of onset of microalbuminuria. Olmesartan have nephroprotective, antioxidant, antifibrotic activities and proteinuria reducing effects which can be beneficial in patients with hypertension. Olmesartanis believed to produce antiproteinuric effects through different mechanisms. It is indicated for treatment of hypertension to reduce the risk of fatal and non fatal CV events which may or may not be associated with proteinuria.
Authors and Affiliations
Satyanarayan Routray, VN Shah, Abhay Sahoo, Priti Sanghavi, Amit Omprakash Gupta, Onkar C Swami
Keywords
Related Articles
- EP ID EP519622
- DOI 10.7860/JCDR/2018/32522.11199
- Views 49
- Downloads 0
Emphysematous Pyelonephritis Caused by E.Coli and Candida Albicans with Oral Candidiasis and Herpes Genitalis: A Dreaded Infection
Abstract Emphysematous Pyelonephritis (EPN) is a rare, potentially fatal necrotising pyelonephritis, with rising trend in diabetic patients (95%). E.coli is the most common uropathogen whereas Candida albicans is extreme...
A study on Association of Antioxidant Status of Red Blood Cells with Type 2 Diabetes
ABSTRACT Introduction: Oxidative stress plays a role in the pathogenesis of type 2 Diabetes either by effecting insulin secretion or increasing resistance to insulin. Oxidative stress is dealt by the body with the help o...
Prevention of Severe Tongue Biting in a Mentally Challenged Patient: A Clinical Report
ABSTRACT Orofacial dysfunctions and habits are the main factors which influence the development of malocclusion and perioral disease. In this context, Orthodontics, a field of Dentistry, is closely associated with the d...
Actinomycosis Calcaneum- A Rare Case Report
Actinomyces is anaerobic, gram-positive bacilli that superficially resemble fungi and give rise to suppurative and granulomatous infection. The organisms are commensals to human body but under suitable conditions can inv...
Carbamazepine Induced Thrombocytopenia
Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On expl...