Omeprazole: A Cause of Vitamin B12 Deficiency - A Hospital-Based Study
Journal Title: Journal of Indus Medical College - Year 2019, Vol 2, Issue 2
Abstract
This cross sectional prospective research study was done in the Department of Medicine, Indus Medical College, Tando Muhammad Khan. Study duration was from 05 February 2018 to 06 February 2019. It included all patients both female and male. All patients above 15 years of age, of either gender with history of recurrent abdominal pain, dyspepsia or abdominal discomfort, heartburn, GERD, H. Pylori positive patients, patients with gastritis, esophagitis, peptic and duodenal ulcer, bloating and halitosis through outdoor patient department (OPD), were enrolled in the study. The detailed history of all such patients was taken and complete physical and relevant clinical examination was performed. Vitamin B12 deficiency was considered when serum B12 level was <350 pg/ml. The informed consent was taken from every patient or from attendants of patients after full explanation of procedure regarding the study and all such manoeuvres was performed under medical ethics and through the cooperation of whole research team. The study was conducted in compliance with the ethical principles of the Declaration of Helsinki. Venous blood samples were collected in the morning after an overnight fast from 11.00 pm for Vitamin B12 levels. During one year study period, 250 patients on long term use of omeraparzole were studied for vitamin B12 deficiency, of which 143 (57.2%) were males and 107(42.8%) were females. The observed symptoms included recurrent abdominal pain in 38(15.2%), dyspepsia or abdominal discomfort in 40(16%), heartburn in 50(20%), bloating in 13(5%), halitosis in 08(3.2%) and combined / mixed symptoms in 17(11%) patients. Of two hundred fifty patients, 120 (48%) had raised MCV with vitamin B12 deficiency.
Authors and Affiliations
Ramesh Kumar Suthar, Kavita Bai, Madiha Zaki
Keywords
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