Omeprazole affects neither electroconvulsive threshold nor anticonvulsant activity of diphenylhydantoin and carbamazepine in mice.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 4
Abstract
Omeprazole is a commonly prescribed drug for patients with peptic ulcerations. Its main mechanism of action is related to inhibition of H(+)-K(+)-ATP-ase, albeit it may also block carbonic anhydrase. This study evaluates the effects of acute and prolonged (3- or 7-day) intragastrical administration of omeprazole on the anticonvulsant activity of carbamazepine or diphenylhydantoin against maximal electroshock-induced seizures in mice. Omeprazole administered acutely, for 3 days or 7 days did not alter the electroconvulsive threshold in mice. Moreover, the drug did not affect the anticonvulsant activity of the tested antiepileptic drugs.
Authors and Affiliations
Mariusz Świąder, Jarogniew Łuszczki, Sławomir Pilip, Maria Kozicka, Jolanta Parada-Turska, Stanisław Czuczwar
Keywords
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