On the treatment of degeneration of the macula and posterior pole
Journal Title: Офтальмологический журнал - Year 2019, Vol 0, Issue 1
Abstract
Background: The field of degeneration of the macula and posterior pole (DMPP) is of outstanding medical and social significance as the disease is of high prevalence and leads to loss of general working capacity. Purpose: To determine the efficacy of conservative treatment with endonasal iontophoresis of Omk2, and the degree of stabilization of visual functions after this treatment in patients with DMPP. Materials and Methods: Thirty-two patients (45 eyes; age, 51 to 75 years) with DMPP were examined and received treatment with endonasal iontophoresis of Omk2. The eye examination included visual acuity, retinal light sensitivity, threshold assessment with macula tester, perimetry and ophthalmoscopy, and was performed before and after treatment. Results: In all patients with DMPP, iontophoresis of Omk2 contributed to apparent improvement in functional activity of the retina, which was achieved due to antioxidative, neurotropic, anti-edema and anti-angiogenetic properties of the drug. In particular, mean uncorrected visual acuity (UCVA) in patients of group 1 improved by 25%, from 0.6 to 0.85, and UCVA in 49% of patients of group 2 improved by 0.01-0.02, which improved the level of social rehabilitation of these patients. In patients with DMPP, the treatment with iontophoresis of Omk2 resulted in improvements in the functional activity of the retinal photopic system and foveal afferent system (as assessed by the Haidinger’s brushes test), and retinal blood flow in the posterior pole (as assessed by the blue field technique) by 33-43%, 14%, and 40%, respectively. This demonstrates that the treatment strategy has the beneficial impact on the function of the visual system, and iontophoresis of Omk2 is a pathogenetically reasonable approach to the management of DMPP. Conclusion: Iontophoresis of Omk2 was found to be beneficial for the function of the visual system, and a pathogenetically reasonable approach to the management of DMPP.
Authors and Affiliations
N. Konovalova, O. Guzun, T. Serebrina
Keywords
Related Articles
- EP ID EP492170
- DOI 10.31288/oftalmolzh201912328
- Views 88
- Downloads 0
Clinical and diagnostic value of impairments in electrolyte metabolism in children with acquired myopia
Background: Identifying the biochemical features of the body in myopia associated with connective tissue dysplasia is still important in the ophthalmologist’s practice. Purpose: To assess the clinical and diagnostic val...
Indications for inpatient treatment of cataract
Purpose: To develop indications for inpatient cataract treatment based on the retrospective review of case histories of cataract patients. Materials and Methods: We retrospectively reviewed 636 case histories of catarac...
Value of static automated perimetry in assessing visual impairments in patients with pituitary adenoma with suprasellar extension
Background: Pituitary adenoma (PA) is a neoplasm that develops from anterior pituitary cells and accounts for 20-25% of all intracranial extracerebral tumors. In a functioning PA, a specific clinical syndrome develops, a...
Current surgical rehabilitation techniques for patients with total bilateral symblepharon
Purpose: To investigate the efficacy of a three-stage surgical rehabilitation technique for patients with bilateral total symblepharon; the technique has been developed and advanced and is being used at present at the Oc...
Soft-tissue response to synthetic polymer implants made of cross-linked polyurethane and containing a biologically active substance, albucid or dacarbazine, in animals
Background: It is an urgent task of the today’s science to search for and introduce biointegrable synthetic materials into medical practice. Purpose: To investigate the soft tissue response to the polymer sample implant...