One pot conventional synthesis and biological activity of some novel double schiff bases
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 5
Abstract
In this work, we report the synthesis and biological activity of some new double Schiff bases derived from ethylene diamine with 2-acetylnaphthalene and 2-acetylpyridine and were characterised by using UV-Visible, FTIR, 1HNMR and 13C NMR spectroscopy studies. All of the synthesized compounds gave satisfactory analytical and spectroscopic data. We explored the antibacterial activity of the synthesized compounds against Esherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the results showed that the compounds exhibits appreciable activity against the selected bacterial strains. The investigation of antifungal screening of the compounds against Aspergillus niger, Candida albicans and Cryptococcus explored that the Schiff bases showed a significant activity against the selected fungal strains.
Authors and Affiliations
I. Salim Meeran*| Aalim Muhammed Salegh College of Engineering, Avadi–IAF, Chennai-55, TN, India., S. Syed Tajudeen| C. Abdul Hakeem College. Melvisharam – 632 509, Vellore District, TN, India., A. Sakhoor Basha| C. Abdul Hakeem College. Melvisharam – 632 509, Vellore District, TN, India.
Keywords
Related Articles
- EP ID EP1627
- DOI -
- Views 503
- Downloads 21
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF NOVEL PYRAZOLONE DERIVATIVES
Pyrazolones, versatile nitrogen containing heterocyclic compounds displaying broad spectrum of biological and pharmacological activities. The main objective of the present study was to explore newer molecules with potent...
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF NOVEL SERIES OF BIS-IMIDAZO[1,2-a]PYRIDINE DERIVATIVES
imidazo[1,2-a]pyridine. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has b...
A brief study on zingiber officinale-A review
Ginger is one of the important medicinal plants which naturally occur in various countries. Ginger; Zingiber officinale belongs to family Zingiberaceae. Young ginger rhizomes are juicy and fleshy with a very mild taste....
A RECENT TRENDS IN ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF POORLY SOLUBLE HYDROPHOBIC DRUGS BY USING PHYSICAL AND CHEMICAL MODIFICATIONS
The aim of this review was to improve the solubility and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The ability to increase aqueous...
EVALUTION OF NORMAL PHARMACEUTICAL CARE SERVICES FOR ASTHMA PATIENTS
To study the pharmaceutical care services on asthma related quality of life. As asthma is associated with an enormous social, psychological, and economic burden, various patient education programs have been developed to...